0000000000246307
AUTHOR
Monica Ramos
Reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones with two equivalents of chalcones
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with two equivalents of the chalcones 2 leads in an acidic medium to the formation of the 2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-one derivatives 3a-d. The structure elucidation of the products is based on nmr measurements and an X-ray diffraction.
ChemInform Abstract: Reaction of 4,5-Diamino-1,6-dihydropyrimidin-6-ones with Two Equivalents of Chalcones.
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with two equivalents of the chalcones 2 leads in an acidic medium to the formation of the 2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-one derivatives 3a-d. The structure elucidation of the products is based on nmr measurements and an X-ray diffraction.
ChemInform Abstract: The Reaction of Aromatic α,β-Unsaturated Ketones with 4,5- Diamino-1,6-dihydropyrimidin-6-ones.
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4-diaryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-ones 3a-m. The structure elucidation of the products is based on detailed nmr investigations including selective 13C[1H] decoupling experiments.
The reaction of aromatic α,β-unsaturated ketones with 4,5-diamino-1,6- dihydropyrimidin-6-ones
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4-diaryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-ones 3a-m. The structure elucidation of the products is based on detailed nmr investigations including selective 13C[1H] decoupling experiments.