0000000000296774
AUTHOR
J.-n. Bastie
Targeting localization of the Il-7 Receptor within lipid rafts as a therapeutic strategy for T-Cell acute lymphoblastic leukemia
IF 7.702; International audience
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells
MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, abnormal levels of HOX transcription factors have been found to be critical for leukemogenesis. We show that MOZ and MLL cooperate to regulate these key genes in human cord blood CD34+ cells. These chromatin-modifying enzymes interact, colocalize and functionally cooperate, and both are recruited to multiple HOX promoters. We also found that WDR5, an adaptor protein essential fo…
Une cause rare d’opacités alvéolaires : maladie de Waldenström à localisation pulmonaire
Resume Introduction Les localisations pulmonaires de la maladie de Waldenstrom sont rares. Observation Nous rapportons le cas d’une femme de 71 ans presentant une toux chronique, associee a des opacites alveolaires disseminees persistantes apres plusieurs antibiotherapies. L’examen clinique etait normal. Le diagnostic de maladie de Waldenstrom etait suspecte devant un pic monoclonal de type IgM (immunoglobuline M) a l’electrophorese des proteines plasmatiques avec immunofixation et la presence d’une population B monoclonale a l’immunophenotypage du lavage broncho-alveolaire. Ce diagnostic etait confirme par le resultat de la biopsie osteomedullaire. La patiente etait traitee par chimiothera…