0000000000299725
AUTHOR
F. Gohlke
Tubulointerstitielle-Nephritis-Uveitis-Syndrom (TINU-Syndrom)
Abstract For 10 weeks a 25-year-old man had been suffering from tiredness, fatigue, nausea and a 16 kg weight loss. Erythrocyte sedimentation rate (83/133 mm), serum C-reactive protein (5.5 mg/dl) and creatinine (5.05 mg/dl) were all elevated. He also had proteinuria (1120 mg daily), sterile leukocytosis and a creatinine clearance of 10 ml/min. Renal biopsy showed interstitial nephritis and bone marrow biopsy revealed non-caseous epithelioid-cell granulomas. 14 days after admission he developed acute iritis in the right eye. Other causes having been excluded, the diagnosis of tubulo-intestinal nephritis with uveitis (TINU syndrome) was made. The clinical symptoms and laboratory findings imp…
Autoimmune findings resembling connective tissue disease in a patient with Castleman's disease.
Multicentric angiofollicular lymphnode hyperplasia (multicentric Castleman's disease) may be associated with acute phase reaction and several autoimmune features. Since lymphadenopathy is a common feature in connective tissue disease, a clear distinction between the different disease entities may be difficult. We describe a 26-year-old male patient with predominant cervical lymphadenopathy, hepatosplenomegaly and polyserositis, diagnosed as collagen disease. He showed several autoimmune features including autoimmune haemolytic anaemia, cryoglobulinaemia, positive antinuclear and anti smooth muscle antibodies, serum immune complexes and a sensorimotor polyneuropathy. Under immunosuppressive …
Prospektive Beobachtungsstudie zur operativen Therapie des renalen Hyperparathyreoidismus
In einer prospektiven Beobachtungsstudie bei Patienten mit renalem Hyperparathyreoidismus wurden nach Eingriffen an den Nebenschilddrusen der Verlauf und die Abhangigkeit der Symptomatik von praoperativ ermittelten Laborparametern analysiert. Zwischen dem 1. 8. 1987 und dem 31. 12. 1995 wurden 79 Patienten operiert. Bei 72 Patienten erfolgten erstmalige Eingriffe an den Nebenschilddrusen. Bevorzugtes Operationsverfahren war die totale Parathyreoidektomie mit autologer Epithelkorperchenreplantation (n = 67). Informationen zum postoperativen Verlauf liegen von allen Patienten vor. Bei 74 der 79 Patienten erfolgten regelmasige Nachuntersuchungen (1–9, Median = 4) mit einer Nachbeobachtungszeit…