6533b7d7fe1ef96bd1268578
RESEARCH PRODUCT
Tubulointerstitielle-Nephritis-Uveitis-Syndrom (TINU-Syndrom)
Elisabeth HermannE. WandelK H Meyer Zum BüschenfeldeM. ChristmannF. Gohlkesubject
AdultMalemedicine.medical_specialtyTime FactorsBiopsyInterstitial nephritisIritisRenal functionKidneyKidney Function TestsGastroenterologyDiagnosis DifferentialUveitischemistry.chemical_compoundPrednisoneInternal medicineHumansMedicineLeukocytosisCreatininemedicine.diagnostic_testbusiness.industrySyndromeGeneral Medicinemedicine.diseaseEndocrinologychemistryErythrocyte sedimentation rateAcute DiseaseNephritis InterstitialPrednisoneRenal biopsymedicine.symptombusinessNephritismedicine.drugdescription
Abstract For 10 weeks a 25-year-old man had been suffering from tiredness, fatigue, nausea and a 16 kg weight loss. Erythrocyte sedimentation rate (83/133 mm), serum C-reactive protein (5.5 mg/dl) and creatinine (5.05 mg/dl) were all elevated. He also had proteinuria (1120 mg daily), sterile leukocytosis and a creatinine clearance of 10 ml/min. Renal biopsy showed interstitial nephritis and bone marrow biopsy revealed non-caseous epithelioid-cell granulomas. 14 days after admission he developed acute iritis in the right eye. Other causes having been excluded, the diagnosis of tubulo-intestinal nephritis with uveitis (TINU syndrome) was made. The clinical symptoms and laboratory findings improved within a few days of the start of glucocorticoid treatment (initially, 100 mg prednisone daily, reduced to 5 mg within 30 days). The patient was discharged after 8 days in good general condition.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-05-26 | DMW - Deutsche Medizinische Wochenschrift |