Corticosterone levels and behavioral changes induced by simultaneous exposure to chronic social stress and enriched environments in NMRI male mice

Environmental enrichment (EE) is an experimental model which is believed to counteract some of the effects induced by stressors, although few studies have exposed rodents simultaneously to EE and stress. Our aim was to compare the short- and long-term effects of different housing conditions in mice submitted to chronic stress. 128 NMRI male mice arrived at our laboratory on postnatal day (PND) 21. During Phase I (PND 28), animals were randomly assigned to four experimental conditions: 1) EE+STRESS: mice housed in EE and submitted to social stress (n=32); 2) EE+NO STRESS: mice housed in EE without stress (n=32); 3) SE+STRESS: mice maintained in standard conditions (SE) and submitted to socia…

El uso de las redes sociales en la docencia universitaria: estudio piloto con Instagram

Instagram es una red social atractiva y versátil muy utilizada por jóvenes y adolescentes. Además de ser una herramienta interesante para contactar con otros o llenar el tiempo libre, puede tener una gran utilidad en el proceso de enseñanza-aprendizaje, ya que los alumnos dedican mucho tiempo a su uso y les resulta muy atractiva. En el presente trabajo se muestra un estudio piloto basado en un proyecto de innovación educativa desarrollado con el objetivo de fomentar el uso de Instagram como recurso educativo en la docencia universitaria de asignaturas de Psicobiología. Se propuso a los estudiantes que buscaran avances científicos recientes relacionados con el área de Psicobiología y Neuroci…

Effectiveness of Virtual Reality for Children and Adolescents with Autism Spectrum Disorder: An Evidence-Based Systematic Review

Autism Spectrum Disorder (ASD) is a neurodevelopmental disease that is specially characterized by impairments in social communication and social skills. ASD has a high prevalence in children, affecting 1 in 160 subjects. Virtual reality (VR) has emerged as an effective tool for intervention in the health field. Different recent papers have reviewed the VR-based treatments in ASD, but they have an important limitation because they only use clinical databases and do not include important technical indexes such as the Web of Science index or the Scimago Journal & Country Rank. To our knowledge, this is the first contribution that has carried out an evidence-based systematic review includin…

Mindfulness y duelo: programa MADED, mindfulness para la aceptación del dolor, las emociones y el duelo

Objective: to design a psychological intervention protocol for the accompaniment of pain and emotions in the grieving process based on attention and compassion. Method: mourners over 18 years of age, who have lost their family member at least 6 months ago, who are in phase 2 or 3 of the grieving process and who have no previous mental health problems, will be included. They will be evaluated after signing the informed consent, by means of: the Mindfulness Questionnaire, the Life Satisfaction Questionnaire, the Vitality Questionnaire, the Hospital Anxiety and Depression Scale, the Positive and Negative Affect Scale and the Complicated Grief Inventory. Descriptive statistics, Cohen’s t-test f…

The Multicultural Personality Questionnaire (SF-40): Adaptation and Validation of the Spanish Version.

The coexistence of diverse cultures in our society indicates the need to examine the factors related to the success of multicultural interactions. The study aims were to examine the psychometric characteristics of the Spanish version of the Multicultural Personality Questionnaire short form (MPQ-SF40), in a convenience sample of 392 university students. Then, the effect of sex and age was assessed, and finally, the levels and percentiles of multicultural personality were measured. The scale’s validity was assessed with exploratory and confirmatory factor analysis (EFA and CFA). Reliability was evaluated with Cronbach’s alpha, composite reliability (CR), and average variance extracted (AVE).…

Nicotina y modelos animales: ¿qué nos aporta el paradigma de enriquecimiento ambiental?

El Enriquecimiento Ambiental (Environmental Enrichment o EE) es un modelo de alojamiento basada en la estimulacion a nivel fisico, cognitivo y sensorial de roedores. Esta condicion se caracteriza por el alojamiento de un grupo de animales en cajas grandes que contienen distintos objetos como tuneles, juguetes y ruedas de correr. El principal objetivo del presente trabajo es plantear los principales argumentos que sugieren que el alojamiento en condiciones de EE puede disminuir la vulnerabilidad a desarrollar adiccion a la nicotina y a otras drogas de abuso, asi como revisar estudios experimentales recientes relacionados con este area. Con este fin, se presenta una revision de los principale…

Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice

Abstract Environmental enrichment (EE) is an experimental paradigm which provides sensory, social, physical and cognitive stimulation for rodents. Experimental evidence indicates that this type of housing induces different neurobiological and behavioral changes. However, few studies have evaluated the consequences of combined exposure to an enriched environment and nicotine administration during a critical period of development such as adolescence. Taking into account previous studies, it can be hypothesized that a chronic treatment with nicotine would modulate the effects of rearing animals in enriched environments. In the current study, our main aim was to evaluate the effects of EE and c…

Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice.

Enriched environments and exercise provide complex environmental stimulation that can induce emotional and cognitive changes; however, few studies have evaluated the effects of these two components on other behaviours, such as novelty seeking or pain sensitivity. The aim of the present study was to investigate the influence of voluntary physical activity provided through different housing conditions on anxiety, locomotor activity, pain sensitivity, and exploration. Male mice at postnatal day (PND) 21 and were randomly assigned to one of four different conditions on PND 28: Marlau cages (MC), a standardized cage designed to provide a complex environment; physical exercise in large groups (PE…

Cuidado de pacientes oncológicos: una revisión sobre el impacto de la situación de estrés crónico y su relación con la personalidad del cuidador y otras variables moduladoras

Objetivo: La incidencia y prevalencia de enfermedades de larga duración como el cáncer se ha incrementado en los últimos años. En este contexto, nuestro principal objetivo será el análisis de las principales consecuencias que la exposición a una situación de estrés crónico, como es el cuidado de un paciente oncológico, tiene sobre la salud psicosocial y la función cognitiva del cuidador informal y su relación con variables moduladoras. Método: Se realizó una revisión bibliográfica en las bases de datos PubMed y PsychINFO sobre las consecuencias de la situación de cuidado en pacientes crónicos. Resultados: Diversos estudios sugieren que la condición de cuidador de un paciente oncológico pued…

Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987.

Abstract Environmental enrichment is an experimental model in which rodents are housed in complex environments that favor lower levels of anxiety-like behavior. PNU-282987 (PNU) is a α7 nicotinic acetylcholine receptor agonist with beneficial effects on learning though its effects on anxiety are unclear. Our main aim was to carry out a study of its effects in NMRI ( n  = 96) mice reared in different environments: environmental enrichment (EE), Marlau™ cages (MC) and standard environment (SE). After a 4-month period, mice received acute treatment of PNU (2.5, 5 and 10 mg/kg) and were evaluated in the elevated plus-maze (EPM) and hole-board (HB). In the EPM, both EE and MC reared mice showed …

An Animal Model of Alcohol Binge Drinking: Chronic-Intermittent Ethanol Administration in Rodents

Binge drinking (BD), characterized by intermittent consumption of large quantities of alcohol in short periods of time, is the main alcohol consumption pattern in adolescents and young adults. BD has serious biomedical consequences, and it is a prominent risk factor for later development of alcohol use disorders. Rodent models offer exceptional power to study these negative consequences of BD. This chapter focuses on one of these BD models: the chronic-intermittent ethanol administration (CIEA) paradigm. Essentially, CIEA consists of the administration in rats or mice of i.p. injections of ethanol (doses: 3-4 g/kg) for several consecutive days each week, in alternation with several days wit…

Altered cerebral blood flow velocity features in fibromyalgia patients in resting-state conditions

[EN] The aim of this study is to characterize in resting-state conditions the cerebral blood flow velocity (CBFV) signals of fibromyalgia patients. The anterior and middle cerebral arteries of both hemispheres from 15 women with fibromyalgia and 15 healthy women were monitored using Transcranial Doppler (TCD) during a 5-minute eyes-closed resting period. Several signal processing methods based on time, information theory, frequency and time-frequency analyses were used in order to extract different features to characterize the CBFV signals in the different vessels. Main results indicated that, in comparison with control subjects, fibromyalgia patients showed a higher complexity of the envel…

Potential Benefits and Limitations of Enriched Environments and Cognitive Activity on Age-Related Behavioural Decline

The main aim of this chapter is to review preclinical studies that have evaluated interventions which may aid in preventing or delaying age-related behavioural decline. Animal models of Environmental Enrichment (EE) are useful for evaluating the influence of cognitive, physical and social stimulation in mitigating cognitive decline at different ages. The EE paradigm has been proposed as a non-invasive treatment for alleviating age-related memory impairment and neurodegenerative diseases. While in this complex environment, rodents can be stimulated at different levels (physical, social, cognitive and sensorial), although a synergism between all these components is likely to play an important…

Editorial: Environmental enrichment as a treatment? Epigenetic mechanisms, challenges and limitations

Methods for Evaluating the Interaction Between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction

The environmental enrichment (EE) paradigm has been evaluated as a means of counteracting some of the consequences of chronic stress in rodents as well as a model of protective environment against drug abuse development. In the present chapter, our main aim is to describe the models of EE and chronic social stress and how they can be applied jointly in order to evaluate the effects of early psychosocial stress in animals exposed of different environments (enriched environment or standard environment). Furthermore, both paradigms could be applied in animal models of nicotine addiction, so the guidelines for the application of a chronic oral nicotine treatment in mice will be described. The h…

Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

Environmental enrichment (EE) is an experimental paradigm in which rodents are housed in complex environments containing objects that provide stimulation, the effects of which are expected to improve the welfare of these subjects. EE has been shown to considerably improve learning and memory in rodents. However, knowledge about the effects of EE on social interaction is generally limited and rather controversial. Thus, our aim was to evaluate both novel object recognition and agonistic behavior in NMRI mice receiving EE, hypothesizing enhanced cognition and slightly enhanced agonistic interaction upon EE rearing. During a 4-week period half the mice (n = 16) were exposed to EE and the other…

Animal Models of Adolescent Binge Drinking

The Mediational Role of Burden and Perceived Stress in Subjective Memory Complaints in Informal Cancer Caregivers.

The role of informal caregiver of cancer patients is considered a situation of chronic stress that could have impact on cognitive functioning. Our aim was to evaluate differences in perceived stress, subjective memory complaints, self-esteem, and resilience between caregivers and non-caregivers, as well as the possible mediational role of burden in caregivers. The sample was composed of 60 participants divided into two groups: (1) Primary informal caregivers of a relative with cancer (CCG) (n = 34)

Enriched Environments for Rodents and their Interaction with Nicotine Administration

An active lifestyle throughout the life cycle seems to delay cognitive aging and dementia and has also been evaluated as an intervention against addiction to cocaine and other drugs of abuse. In epidemiological studies with humans, it has proved difficult to separate the cognitive, social and physical components from other variables that influence lifestyle. Studies in animal models are useful for evaluating the impact of each of these factors and for uncovering the underlying mechanisms of the benefits of complex environments. Preclinical studies have employed the Environmental Enrichment paradigm (EE) which has been proposed as a preclinical model of positive life experiences in humans. E…

Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

Prior studies have suggested that short periods of exposure to environmental enrichment (EE) in rodents induce physiological and behavioral effects. In the present study, our aim was to evaluate if the impact of experiences based on EE could be modulated by the age of onset and the developmental period of exposure. NMRI male mice (n = 64) were exposed to EE or standard environment (SE) and behavioral changes (anxiety, exploration, memory and social interaction) were evaluated. Groups compared were: (a) SE: exposure to SE on post-natal day (PND) 28 and lasting 6 months; (b) EE-6: exposure to EE on PND 28 and lasting 6 months; (c) EE-4: exposure to EE on PND 91 and lasting 4 months; (d) EE-2:…