0000000000371390
AUTHOR
Alejandro Rodriguez
HLA-DQ: Celiac diseasevsinflammatory bowel disease
Aim To determine the genetic predisposition to celiac disease (CeD) in inflammatory bowel disease (IBD) patients by quantifying the frequency of CeD-related human leucocyte antigen (HLA) (HLA-CeD: HLA-DQ2 and -DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD disease. Methods We conducted a prospective study with IBD patients from our Unit. Clinical information was gathered and blood was tested for HLA-CeD. The control group was made up of unrelated Valencian organ donors. Results 1034 subjects were analyzed: 457 IBD [207 ulcerative coliti (UC) and 250 Crohn's disease (CD)] patients…
Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease.
Several neurological disorders have been linked to mutations in chaperonin genes and more specifically to the HSPD1 gene. In humans, HSPD1 encodes for the mitochondrial Heat Shock Protein 60 (mtHsp60) chaperonin, which carries out essential protein refolding reactions that help maintain mitochondrial and cellular homeostasis. It functions as a macromolecular complex that provides client proteins an environment that favors proper folding in an ATP dependent manner. It has been established that mtHsp60 plays a crucial role in the proper folding of mitochondrial proteins involved in ATP producing pathways. Recently, various single-point mutations in the mtHsp60 encoding gene have been directly…
Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia
Background: Aspiration community-acquired pneumonia (ACAP) and community-acquired pneumonia (CAP) in patients with aspiration risk factors (AspRFs) are infections associated with anaerobes, but limited evidence suggests their pathogenic role. Research Question: What are the aspiration risk factors, microbiology patterns, and empiric anti-anaerobic use in patients hospitalized with CAP? Study Design and Methods: This is a secondary analysis of GLIMP, an international, multicenter, point-prevalence study of adults hospitalized with CAP. Patients were stratified into three groups: (1) ACAP, (2) CAP/AspRF+ (CAP with AspRF), and (3) CAP/AspRF- (CAP without AspRF). Data on demographics, comorbidi…
DATOS CLÍNICOS NO INVASIVOS RELACIONADOS CON LA MORTALIDAD DE PACIENTES CON INGESTA DE CÁUSTICOS
Introduccion La mortalidad inmediata en la ingesta causticos se relaciona con la intensidad de las lesiones esofagogastricas; ocasionalmente no es factible realizar endoscopia por malas condiciones clinicas del paciente/negativa de este/no disponibilidad de la tecnica; en esta situacion la valoracion de la gravedad del paciente y posible evolucion fatal se debe realizar mediante datos clinicos y analiticos. Objetivos Identificar los datos clinicos relacionados con la mortalidad de pacientes con ingesta de causticos. Material y metodos Estudio prospectivo protocolizado (1995–2008) incluyendo datos demograficos, clinicos, analiticos, endoscopicos y evolutivos sobre 242 pacientes (107 hombres …