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RESEARCH PRODUCT
HLA-DQ: Celiac diseasevsinflammatory bowel disease
Samuel NavarroFrancisco MoraMarta Maia Bosca-wattsJoan ToscaMiguel MinguezDolores PlanellesJesus M. SantiagoAlejandro Rodriguezsubject
medicine.medical_specialtyCrohn's diseaseHLA-DQB1business.industryGastroenterologynutritional and metabolic diseasesGeneral MedicineHuman leukocyte antigenmedicine.diseaseGastroenterologyInflammatory bowel diseaseUlcerative colitis03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisInternal medicineHLA-DQGenetic predispositionMedicine030211 gastroenterology & hepatologybusinessProspective cohort studydescription
Aim To determine the genetic predisposition to celiac disease (CeD) in inflammatory bowel disease (IBD) patients by quantifying the frequency of CeD-related human leucocyte antigen (HLA) (HLA-CeD: HLA-DQ2 and -DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD disease. Methods We conducted a prospective study with IBD patients from our Unit. Clinical information was gathered and blood was tested for HLA-CeD. The control group was made up of unrelated Valencian organ donors. Results 1034 subjects were analyzed: 457 IBD [207 ulcerative coliti (UC) and 250 Crohn's disease (CD)] patients and 577 healthy controls. 39% of the controls and 34% of the patients had HLA-CeD (P = 0.0852). HLA-DQ2 was less frequent in UC patients (P = 0.0287), and HLA-DQ8 in CD (P = 0.0217). In women with UC, the frequency of DQ2.5cis (DQB1*02:01-DQA1*05:01) was reduced ≥ 50% [P = 0.0344; preventive fraction (PF) = 13%]. PFs (7%-14%) were obtained with all HLA-CeD haplotypes. HLA DQB1*02:02-DQA1*02:01 (HLA-DQ2.2) was more frequent in CD patients with respect to controls (P = 0.001) and UC patients (etiological fraction = 15%). Conclusion HLA-CeD is not more frequent in IBD patients, with an even lower frequency of HLA-DQ2 and -DQ8 in UC and CD respectively. HLA-DQ2.5 confers protection from the development of UC, especially in women, and HLA-DQ8 does so for the appearance of CD. HLA-DQ2.2 is present in 34% of the CD patients and may constitute a genetic risk factor for CD development.
year | journal | country | edition | language |
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2018-01-07 | World Journal of Gastroenterology |