0000000000391415

AUTHOR

M. C. Zafra‐polo

showing 3 related works from this author

Acetogenins from Annonaceae: Recent Progress in Isolation, Synthesis and Mechanisms of Action

2005

Covering: the literature from 1998 to 2004 The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such interesting natural products. In fact, of the 417 isolated compounds reviewed, over 176 have been added during the period from 1998 to 2004.

AcetogeninsIsolation (health care)StereochemistryAnnonacinAnnonaceaeComputational biologyBiochemistryLactoneschemistry.chemical_compoundDrug DiscoverymedicineMolecular StructureTraditional medicinebiologyChemistryOrganic ChemistryGeneral Medicinebiology.organism_classificationAntineoplastic Agents PhytogenicAction (philosophy)Mechanism of actionAnnonaceaeAcetogeninFatty AlcoholsAnnonaceous Acetogeninsmedicine.symptomBullatacinChemInform
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Epoxy-Acetogenins and other Polyketide Epoxy Derivatives as Inhibitors of the Mitochondrial Respiratory Chain Complex I

2000

Annonaceous acetogenins (ACG), an extensive group of cytotoxic natural products, are antitumor agents whose main mode of action is inhibition of the mammalian mitochondrial complex I. Herein we describe the importance of the different chemical groups along the alkyl chain for optimal inhibitory potency, discussing the structurally relevant factors present in these compounds. For this purpose, a series of epoxide derivatives from alpha-linolenic acid were prepared and their activity compared with that of epoxy-acetogenins and tetrahydrofuranic (THF) acetogenins isolated from Rollinia membranacea.

StereochemistryChemical structurePharmaceutical ScienceEpoxideAnalytical ChemistryElectron TransportLactonesPolyketidechemistry.chemical_compoundDrug DiscoveryNADH NADPH OxidoreductasesMitochondrial respiratory chain complex IFuransMode of actionAlkylPharmacologychemistry.chemical_classificationbiologyOrganic ChemistryEpoxybiology.organism_classificationMitochondriaComplementary and alternative medicinechemistryAnnonaceaevisual_artvisual_art.visual_art_mediumEpoxy CompoundsMolecular MedicinePlanta Medica
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Polyalthidin:  New Prenylated Benzopyran Inhibitor of the Mammalian Mitochondrial Respiratory Chain

1996

Polyalthidin (3), a new benzopyran derivative, was isolated from the stem bark of Polyalthia cerasoides. Its structure was established on the basis of chemical and spectral evidence. Polyalthidin has showed potent biological activity as an inhibitor of the mammalian mitochondrial respiratory chain.

Magnetic Resonance SpectroscopyStereochemistryRespiratory chainPharmaceutical ScienceMitochondrionMitochondria HeartPlant EpidermisAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryAnimalsHumansBenzopyransNADH NADPH OxidoreductasesEnzyme InhibitorsPharmacologychemistry.chemical_classificationPlants MedicinalbiologyOrganic ChemistryBiological activityMitochondriaBenzopyranEnzymeMitochondrial respiratory chainComplementary and alternative medicinechemistryBiochemistryEnzyme inhibitorFatty Acids Unsaturatedbiology.proteinMolecular MedicinePolyalthia cerasoidesCattleSpectrophotometry UltravioletJournal of Natural Products
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