6533b851fe1ef96bd12a8dd1

RESEARCH PRODUCT

Polyalthidin:  New Prenylated Benzopyran Inhibitor of the Mammalian Mitochondrial Respiratory Chain

Diego CortesErnesto EstornellTormoM. C. GonzalezM. C. Zafra‐polo

subject

Magnetic Resonance SpectroscopyStereochemistryRespiratory chainPharmaceutical ScienceMitochondrionMitochondria HeartPlant EpidermisAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryAnimalsHumansBenzopyransNADH NADPH OxidoreductasesEnzyme InhibitorsPharmacologychemistry.chemical_classificationPlants MedicinalbiologyOrganic ChemistryBiological activityMitochondriaBenzopyranEnzymeMitochondrial respiratory chainComplementary and alternative medicinechemistryBiochemistryEnzyme inhibitorFatty Acids Unsaturatedbiology.proteinMolecular MedicinePolyalthia cerasoidesCattleSpectrophotometry Ultraviolet

description

Polyalthidin (3), a new benzopyran derivative, was isolated from the stem bark of Polyalthia cerasoides. Its structure was established on the basis of chemical and spectral evidence. Polyalthidin has showed potent biological activity as an inhibitor of the mammalian mitochondrial respiratory chain.

yearjournalcountryeditionlanguage
1996-10-01Journal of Natural Products
https://doi.org/10.1021/np960492m