0000000000420115
AUTHOR
Pilar Sánchez
showing 8 related works from this author
Pigment epithelium-derived factor is a niche signal for neural stem cell renewal.
2006
Adult stem cells are characterized by self-renewal and multilineage differentiation, and these properties seem to be regulated by signals from adjacent differentiated cell types and by extracellular matrix molecules, which collectively define the stem cell "niche." Self-renewal is essential for the lifelong persistence of stem cells, but its regulation is poorly understood. In the mammalian brain, neurogenesis persists in two germinal areas, the subventricular zone (SVZ) and the hippocampus, where continuous postnatal neuronal production seems to be supported by neural stem cells (NSCs). Here we show that pigment epithelium-derived factor (PEDF) is secreted by components of the murine SVZ a…
Organ Donation Related With Attitude Toward the Law of Presumed Consent: Spanish University Medical and Nursing Students Study.
2020
Information provided by health care professionals is crucial to create a climate of social opinion. This is important in organ donation and transplantation (ODT), where the participation of the general public is essential to obtain organs. Objective To determine the attitude toward the Law of Presumed Consent (LPC) among Spanish university students and to analyze their relation with attitude toward ODT. Methods and design. The type of study was a sociologic, multicenter, observational study. The population included medical and nursing students in Spanish universities. Database of Collaborative International Donor Project was used stratified by geographic area and academic course. A validate…
Exploring Health Science Students' Notions on Organ Donation and Transplantation: A Multicenter Study.
2020
The knowledge acquired during university education about organ donation and transplantation (ODT) decisively influences the information future health professionals transmit. This is important in ODT where the participation of the general public is essential to obtain organs. Objective To determine notions of Spanish medicine and nursing students on ODT and its relationship with attitude toward ODT. Methods and Design and design. We conducted a sociologic, multicenter, and observational study. The population for our study consisted of medical and nursing students in Spanish universities. Our database was the Collaborative International Donor Project, stratified by geographic area and academi…
Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.
2010
SummaryStem cell division can result in two sibling cells exhibiting differential mitogenic and self-renewing potential. Here, we present evidence that the dual-specificity kinase Dyrk1A is part of a molecular pathway involved in the regulation of biased epidermal growth factor receptor (EGFR) signaling in the progeny of dividing neural stem cells (NSC) of the adult subependymal zone (SEZ). We show that EGFR asymmetry requires regulated sorting and that a normal Dyrk1a dosage is required to sustain EGFR in the two daughters of a symmetrically dividing progenitor. Dyrk1A is symmetrically or asymmetrically distributed during mitosis, and biochemical analyses indicate that it prevents endocyto…
Inventario y descripción de las soluciones de accesibilidad a la web existentes para personas con discapacidad fisica y sensorial
2011
El elemento más representativo de la nueva sociedad de la información lo constituye sin duda la World Wide Web. La Red, como es conocida popularmente, une a millones de ordenadores en todo el mundo, aportando una riqueza de información inimaginable hace pocos años y un interfaz de uso tan gráfico e intuitivo que ha significado una expansión permanente de su uso a millones de usuarios nuevos cada año. La accesibilidad Web se puede definir como la posibilidad de que un producto o servicio Web sea usado por el mayor número posible de personas, independientemente de las limitaciones del individuo o de las del contexto de uso. De acuerdo con el Tratado de Amsterdam de la Unión Europea, en aplica…
Confident Perception of Primary Care Physicians Correlates to the Attitude Toward Donation and Organ Transplantation: A Multicenter Study of Medical …
2020
A primary care physician (PCP) not only accompanies the patient in the process of an illness, but throughout his or her life. The confidence we have in these health professionals is fundamental, and their favorable attitude toward organ donation and transplantation (ODT) has a significant influence on the population. Objective To analyze trust in PCPs among Spanish medical and nursing students, the relationship with their attitude toward ODT, and the factors that condition it. Methods and Design A sociologic, multicenter, and observational study. Population: medical and nursing students in Spanish universities. Database: Collaborative International Donor Project, stratified by geographic ar…
A combined ex/in vivo assay to detect effects of exogenously added factors in neural stem cells.
2007
We describe a protocol developed/modified by our group for the ex vivo and in vivo assessment of the response to a soluble factor of murine neural stem cells from the adult sub-ventricular zone (SVZ). The procedure includes several experimental options that can be used either independently or in combination. Potential factor effects on self-renewal, survival and proliferation are assayed by means of neurosphere cultures, with the factor administered directly in vitro to the culture plates (Step 1) or infused in vivo immediately before tissue dissociation (Step 3). We also use bromodeoxiuridine (BrdU) retention to label slowly dividing cells in vivo and subsequently perform two different typ…
Rediseñando la formación-acción de agentes de salud de base comunitaria
2013
Justificación: El diseño de este curso se encuentra dentro del programa MIHSALUD de alta difusión y movilización social en entornos urbanos para empoderar a la comunidad, dirigido a población en situación de vulnerabilidad, de la ciudad de Valencia, dando respuesta a las necesidades de salud detectadas. Objetivo: Describir el diseño de formación-acción de agentes de salud de base comunitaria como herramienta de promoción de la salud y los resultados obtenidos en sus cuatro ediciones 2009/2012. Métodos: Se realiza el diseño del primer curso con metodología participativa y alternando módulos de formación teórica y práctica (FORMACIÓN) con transferencia de la práctica recibida al ámbito asocia…