0000000000525061
AUTHOR
J. Jung
Ist eine ICD-Programmierung auf eine Schockenergie der doppelten intraoperativen Defibrillationsschwelle im Langzeitverlauf sicher effektiv? Ergebnisse einer prospektiven randomisierten Multizenterstudie (Low Energy Endotak Trial – LEET)
Ziel dieser kontrollierten, prospektiven, randomisierten Studie war die Untersuchung der Effektivitat und der Sicherheit einer reduzierten Defibrillationsenergie mit biphasischer Schockform und einem endokardialem ICD-Sondensystem. 176 Patienten, die klinisch ein typisches ICD-Patientenkollektiv darstellten, wurden im Rahmen der Studie untersucht. Alle Patienten erhielten ein ICD-Aggregat mit der Moglichkeit der Episodenspeicherung (Ventak TM PRx II, PRx III) in Verbindung mit einem rein endokardialem Sondensystem (Endotak TM Serie 0070; 0090, CPI). Die intraoperative Defibrillationsschwelle (DFT) sollte ≤15 J betragen. Die DFT wurde in einem Protokoll mit absteigenden Energiemengen (15, 10…
First measurement of the |t|-dependence of coherent J/ψ photonuclear production
The first measurement of the dependence on $|t|$, the square of the momentum transferred between the incoming and outgoing target nucleus, of coherent J/ψ photoproduction is presented. The data were measured with the ALICE detector in ultra-peripheral Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the J/$\psi$ produced in the central rapidity region $|y| < 0.8$, which corresponds to the small Bjorken-$x$ range $(0.3 − 1.4) \times 10 ^{−3}$. The measured $|t|$-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according t…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
The debye-waller factor in spincrossover molecular crystals: a mössbauer study on [FexZn1−x(ptz)6](BF4)2
In a first approximation the Debye-Waller factor (DWF) of molecular crystals is factorized into a molecular and a lattice part:f=f m f l. In the case of spincrossover compounds there is the unique possibility to measure differences of both parts in the two spin states by switching the spin states with the LIESST effect. Measurements of the DWF depending on temperature, γ-ray direction and spin state were performed with57Fe-Mossbauer spectroscopy on three single crystals (R¯3) of the spincrossover system [FexZn1−x(ptz)6](BF4)2 (ptz=1-propyltetrazole), a concentrated sample withx=1 and diluted ones withx=0.30 andx=0.005. The DWF decreases from 10 to 300 K by a factor of ∼ 100 and its anisotro…
Fascinating electronic games in iron complexes
Coordination compounds of transition metal ions with open-shell electron configurations may exhibit dynamic electronic-structure phenomena, depending on the nature of the coordinating ligand sphere. The change of spin state with temperature («thermal spin-crossover»), light-induced electron transfer processes leading to long-lived metastable charge and spin states (e.g., «LIESST» effect), are some of the fascinating electronic games encountered in transition metal compounds, which are presently under extensive study by chemists and physicists. Mossbauer spectroscopy plays a dominant role in the investigation of such phenomena in iron compounds, as will be demonstrated in this paper. This wo…
Search for a common baryon source in high-multiplicity pp collisions at the LHC
Physics letters / B B811, 135849 (2020). doi:10.1016/j.physletb.2020.135849
The upgrade of the ALICE TPC with GEMs and continuous readout
Journal of Instrumentation 16(03), P03022 (2021). doi:10.1088/1748-0221/16/03/P03022
Dielectron production in proton-proton and proton-lead collisions at √sNN=5.02TeV
The first measurements of dielectron production at midrapidity (|ηe| < 0.8) in proton–proton and proton–lead collisions at √sNN = 5.02 TeV at the LHC are presented. The dielectron cross section is measured with the ALICE detector as a function of the invariant mass mee and the pair transverse momentum pT, ee in the ranges mee < 3.5 GeV/c2 and pT, ee < 8 GeV/c, in both collision systems. In proton–proton collisions, the charm and beauty cross sections are determined at midrapidity from a fit to the data with two different event generators. This complements the existing dielectron measurements performed at √s = 7 and 13 TeV. The slope of the √s dependence of the three measurements is…
Measurements of mixed harmonic cumulants in Pb–Pb collisions at sNN=5.02 TeV
Correlations between moments of different flow coefficients are measured in Pb–Pb collisions at sNN=5.02 TeV recorded with the ALICE detector. These new measurements are based on multiparticle mixed harmonic cumulants calculated using charged particles in the pseudorapidity region |η|<0.8 with the transverse momentum range 0.2<pT<5.0 GeV/c. The centrality dependence of correlations between two flow coefficients as well as the correlations between three flow coefficients, both in terms of their second moments, are shown. In addition, a collection of mixed harmonic cumulants involving higher moments of v2 and v3 is measured for the first time, where the characteristic signature of ne…
Reproduzierbarkeit der Defibrillationseffektivität zur Terminierung von induziertem Kammerflimmern unter Verwendung der intraoperativ gemessenen Defibrillationsschwellenenergie bei Patienten mit implantierbarem Kardioverter-Defibrillator
Ziel vorliegender Untersuchung war es, die Reproduzierbarkeit der Effektivitat der nach einem modifizierten Protokoll intraoperativ bestimmten Defibrillationsschwellenenergie im Langzeitverlauf zu uberprufen. Hierzu wurden im Rahmen einer Substudie einer prospektiven, randomisierten Multizenterstudie (“Low Energy Endotak Trial” LEET)) zwischen Dezember 1993 und Januar 1996 83 Patienten, die im Rahmen einer Erstversorgung mit einem implantierbaren Kardioverter-Defibrillator (ICD) in Kombination mit einem transvenosen Einzelelektrodensystem eine intraoperativ bestimmte Defibrillationsschwelle (DFT) ≤15 J aufwiesen, eingeschlossen. Zur Bestimmung der DFT wurde ein Protokoll mit absteigenden En…
[Is ICD-programming for double intraoperative defibrillation threshold energy safe and effective during long-time follow-up? Results of a prospective randomized multicenter study (Low-Energy Endotak Trial--LEET)].
The aim of this prospective and randomized study was to evaluate the safety and efficacy of a reduced shock strength in transvenous implantable defibrillator therapy. So far clinical data concerning the safety margin of the shock energy in ICD therapy do not exist. The shock energy tested during long-term follow-up in this study was twice the intraoperatively measured defibrillation threshold (DFT). A total number of 176 consecutive patients representing a typical cohort of ICD patients were evaluated. All patients received a non-thoracotomy lead system (CPI, Endotak 0070, 0090) and a biphasic cardioverter-defibrillator with the ability to store episodes (Cardiac Pacemakers Inc., Ventac TM …