0000000000528392

AUTHOR

Mohammed O. Abdelaziz

showing 3 related works from this author

OXA-163-Producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010

2012

ABSTRACT Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related β-lactamase able to hydrolyze cephalosporins and carbapenems is especially worrying in a geographic area where OXA-48 is endemic and effective surveillance for antibiotic resistance is largely unaffordable.

AdultDNA BacterialMaleMicrobiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaOXA-163EpidemiologyKlebsiella pneumoniaemedicine.drug_classMolecular Sequence DataCephalosporinSettore MED/42 - Igiene Generale E Applicatabeta-Lactam Resistancebeta-LactamasesTravel abroadMicrobiologyAntibiotic resistancepolycyclic compoundsmedicineHumansOXA-163; Klebsiella pneumoniaebiologyGeographic areaHydrolysisSequence Analysis DNAKlebsiella infectionsbiochemical phenomena metabolism and nutritionbiology.organism_classificationVirologyAnti-Bacterial AgentsCephalosporinsKlebsiella InfectionsKlebsiella pneumoniaeCarbapenemsbacteriaEgyptFemaleJournal of Clinical Microbiology
researchProduct

Cephalosporin resistantEscherichia colifrom cancer patients in Cairo, Egypt

2013

Cephalosporin-resistant Escherichia coli has been increasingly reported worldwide. In this study, 32 cephalosporin resistant E. coli isolates identified from cancer patients in Cairo, Egypt in 2009–2010 were analyzed. Twenty-three were of phylogenetic group D, seven A and one each B1 and B2. By rep-PCR 15 phylogroup D isolates were grouped in four clusters, one with sequence type (ST) 405 and three ST68. Seventeen isolates showed single patterns. blaCTX-M-15 and aac(6')-Ib-cr were the most common resistance determinants. blaOXA-48 and blaVIM were also detected. Multidrug resistant E. coli seriously affects healthcare, especially in immunocompromised hosts, such as cancer patients.

medicine.drug_classImmunologyCephalosporinCancerBiologymedicine.disease_causemedicine.diseaseMicrobiologyVirologyMicrobiologyMultiple drug resistanceVirologymedicineEscherichia coliMicrobiology and Immunology
researchProduct

NDM-1 and OXA-163 producing Klebsiella pneumoniae isolates in Cairo, Egypt, 2012

2013

Here we describe carbapenem resistance determinants in two Klebsiella pneumoniae isolates recovered from two hospitalised patients in the same intensive care unit of a cancer hospital in Cairo, Egypt. PCR and sequencing were used to detect and characterise β-lactamase genes. Clonal relationships between the isolates were analysed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The first K. pneumoniae isolate carried the blaNDM-1 gene and the second isolate carried the blaOXA-163 gene. Both isolates co-expressed the extended-spectrum β-lactamase CTX-M-15. The two isolates belonged to different sequence types (STs), ST11 and ST16, respectively. No history of …

Microbiology (medical)Antimicrobial drug resistanceSettore MED/07 - Microbiologia E Microbiologia ClinicaOXA-163biologyGeographic areaKlebsiella pneumoniaeImmunologyNorth africaSequence typesNDM-1biology.organism_classificationMicrobiologyVirologyMicrobiologyCarbapenemaseKlebsiella pneumoniaeNDM-1; OXA-163; Carbapenemase; Klebsiella pneumoniae; Antimicrobial drug resistancePulsed-field gel electrophoresisImmunology and AllergyMultilocus sequence typingCarbapenem resistance
researchProduct