Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging dat…

Measurement of neutrino-induced charged-current charged pion production cross sections on mineral oil atEν∼1  GeV

Using a high-statistics, high-purity sample of {nu}{sub {mu}-}induced charged current, charged pion events in mineral oil (CH{sub 2}), MiniBooNE reports a collection of interaction cross sections for this process. This includes measurements of the CC{pi}{sup +} cross section as a function of neutrino energy, as well as flux-averaged single- and double-differential cross sections of the energy and direction of both the final-state muon and pion. In addition, each of the single-differential cross sections are extracted as a function of neutrino energy to decouple the shape of the MiniBooNE energy spectrum from the results. In many cases, these cross sections are the first time such quantities…

WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 – Area 5)

Measurement ofνμandν¯μinduced neutral current singleπ0production cross sections on mineral oil atEν∼O(1 GeV)

MiniBooNE reports the first absolute cross sections for neutral current single {pi}{sup 0} production on CH{sub 2} induced by neutrino and antineutrino interactions measured from the largest sets of NC {pi}{sup 0} events collected to date. The principal result consists of differential cross sections measured as functions of {pi}{sup 0} momentum and {pi}{sup 0} angle averaged over the neutrino flux at MiniBooNE. We find total cross sections of (4.76 {+-} 0.05{sub stat} {+-} 0.40{sub sys}) x 10{sup -40} cm{sup 2}/nucleon at a mean energy of = 808 MeV and (1.48 {+-} 0.05{sub stat} {+-} 0.14{sub sys}) x 10{sup -40} cm{sup 2}/nucleon at a mean energy of = 664 MeV for {nu}{sub {mu}} and {bar {nu}…

Measurement ofνμ-induced charged-current neutral pion production cross sections on mineral oil atEν∈0.5–2.0  GeV

The authors would like to acknowledge the support of Fermilab, the Department of Energy, and the National Science Foundation in the construction, operation, and data analysis of the Mini Booster Neutrino Experiment.

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Accepted Article

Dual baseline search for muon neutrino disappearance at0.5  eV2<Δm2<40  eV2

The SciBooNE and MiniBooNE collaborations report the results of a νμ disappearance search in the Δ'm2 region of 0.5-40 eV2. The neutrino rate as measured by the SciBooNE tracking detectors is used to constrain the rate at the MiniBooNE Cherenkov detector in the first joint analysis of data from both collaborations. Two separate analyses of the combined data samples set 90% confidence level (CL) limits on νμ disappearance in the 0.5-40 eV2 Δm2 region, with an improvement over previous experimental constraints between 10 and 30 eV2

Measurement of the Ratio of theνμCharged-Current Single-Pion Production to Quasielastic Scattering with a 0.8 GeV Neutrino Beam on Mineral Oil

Charged current single pion production (CC{pi}{sup +}) and charged current quasi-elastic scattering (CCQE) are the most abundant interaction types for neutrinos at energies around 1 GeV, a region of great interest to oscillation experiments. The cross-sections for these processes, however, are not well understood in this energy range. This dissertation presents a measurement of the ratio of CC{pi}{sup +} to CCQE cross-sections for muon neutrinos on mineral oil (CH{sub 2}) in the MiniBooNE experiment. The measurement is presented here both with and without corrections for hadronic re-interactions in the target nucleus and is given as a function of neutrino energy in the range 0.4 GeV < E{sub…

MOESM1 of Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Additional file 1. IPCRG scaling up activities.

Search for Core-Collapse Supernovae using the MiniBooNE Neutrino Detector

We present a search for core-collapse supernovae in the Milky Way galaxy, using the MiniBooNE neutrino detector. No evidence is found for core-collapse supernovae occurring in our Galaxy in the period from December 14, 2004 to July 31, 2008, corresponding to 98% live time for collection. We set a limit on the core-collapse supernova rate out to a distance of 13.4 kpc to be less than 0.69 supernovae per year at 90% C. L.

Test of Lorentz and CPT violation with short baseline neutrino oscillation excesses

The sidereal time dependence of MiniBooNE ν[subscript e] and ν[over-bar][subscript e] appearance data is analyzed to search for evidence of Lorentz and CPT violation. An unbinned Kolmogorov–Smirnov (K–S) test shows both the ν[subscript e] and ν[over-bar][subscript e] appearance data are compatible with the null sidereal variation hypothesis to more than 5%. Using an unbinned likelihood fit with a Lorentz-violating oscillation model derived from the Standard Model Extension (SME) to describe any excess events over background, we find that the ν[subscript e] appearance data prefer a sidereal time-independent solution, and the ν[over-bar][subscript e] appearance data slightly prefer a sidereal…

Measurement of the neutrino neutral-current elastic differential cross section on mineral oil atEν∼1  GeV

We report a measurement of the flux-averaged neutral-current elastic differential cross section for neutrinos scattering on mineral oil (CH{sub 2}) as a function of four-momentum transferred squared, Q{sup 2}. It is obtained by measuring the kinematics of recoiling nucleons with kinetic energy greater than 50 MeV which are readily detected in MiniBooNE. This differential cross-section distribution is fit with fixed nucleon form factors apart from an axial mass M{sub A} that provides a best fit for M{sub A}=1.39{+-}0.11 GeV. Using the data from the charged-current neutrino interaction sample, a ratio of neutral-current to charged-current quasielastic cross sections as a function of Q{sup 2} …

ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice: Review

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Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organizatio…

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care p…

Search for Muon Neutrino and Antineutrino Disappearance in MiniBooNE

The MiniBooNE Collaboration reports a search for nu(mu) and nu(mu) disappearance in the Delta m(2) region of 0.5-40 eV(2). These measurements are important for constraining models with extra types of neutrinos, extra dimensions, and CPT violation. Fits to the shape of the nu(mu) and nu(mu) energy spectra reveal no evidence for disappearance at the 90% confidence level (C.L.) in either mode. The test of nu(mu) disappearance probes a region below Delta m(2)=40 eV(2) never explored before.

Neutrino flux prediction at MiniBooNE

The booster neutrino experiment (MiniBooNE) searches for nu(mu)->nu(e) oscillations using the O(1 GeV) neutrino beam produced by the booster synchrotron at the Fermi National Accelerator Laboratory). The booster delivers protons with 8 GeV kinetic energy (8.89 GeV/c momentum) to a beryllium target, producing neutrinos from the decay of secondary particles in the beam line. We describe the Monte Carlo simulation methods used to estimate the flux of neutrinos from the beam line incident on the MiniBooNE detector for both polarities of the focusing horn. The simulation uses the Geant4 framework for propagating particles, accounting for electromagnetic processes and hadronic interactions in the…

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

AIMS: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. METHODS: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. STAKEHOLDERS: Incl…

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second c…

Unexplained Excess of Electronlike Events from a 1-GeV Neutrino Beam

The MiniBooNE Collaboration observes unexplained electronlike events in the reconstructed neutrino energy range from 200 to 475 MeV. With 6.46 x 10(20) protons on target, 544 electronlike events are observed in this energy range, compared to an expectation of 415.2 +/- 43.4 events, corresponding to an excess of 128.8 +/- 20.4 +/- 38.3 events. The shape of the excess in several kinematic variables is consistent with being due to either nu(e) and (nu) over bar (e) charged-current scattering or nu(mu) neutral-current scattering with a photon in the final state. No significant excess of events is observed in the reconstructed neutrino energy range from 475 to 1250 MeV, where 408 events are obse…