0000000000660351

AUTHOR

Fb El Amrani

showing 2 related works from this author

Anti-adrenergic effects of ranolazine in isolated rat aorta

2014

Ranolazine, a piperazine derivative, is used as an anti- anginal drug to treat patients with chronic angina in clinical practice [1] and may improve coronary blood flow by reducing compression effects of ischemic contracture, and by improving endothelial function [2],[3]. In the present study we investigate the vascular effects of ranolazine on the endothelium, adrenergic system and Ca2+ in isolated rat aorta.

DrugAortaEndotheliumbusiness.industrymedia_common.quotation_subjectRanolazineAdrenergicChronic anginaBlood flowIschemic ContracturePharmacologyCritical Care and Intensive Care Medicinemedicine.anatomical_structuremedicine.arteryPoster Presentationmedicinebusinessmedicine.drugmedia_commonCritical Care
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Anti-inflammatory and antioxidant effects of ranolazine on primary cultured astrocytes

2014

Because of its ability to block late INa [1], ranolazine is used as an antianginal agent for the treatment of chronic angina pectoris when angina is not adequately controlled by other agents [2]. Besides its cardiovascular effects, ranolazine improves different neuronal functions, and thus its use has been proposed for the treatment of pain and epileptic disorders [3,4]. Since astrocytes are involved in neuronal inflammatory processes, and autoimmune and neurodegenerative diseases [5], we have investigated the antiinflammatory and antioxidant effects of ranolazine in primary cultured astrocytes.

Antioxidantmedicine.drug_classbusiness.industrymedicine.medical_treatmentRanolazineChronic anginaPharmacologymedicine.diseaseCritical Care and Intensive Care MedicineAnti-inflammatoryAnginaPoster Presentationmedicinebusinessmedicine.drugCritical Care
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