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RESEARCH PRODUCT
Anti-inflammatory and antioxidant effects of ranolazine on primary cultured astrocytes
MauricioS GuerraDiana Aguirre-ruedaMartin AldasoroPatricia MarchioJose Mª VilaSoraya L. VallesF FernándezFb El Amranisubject
Antioxidantmedicine.drug_classbusiness.industrymedicine.medical_treatmentRanolazineChronic anginaPharmacologymedicine.diseaseCritical Care and Intensive Care MedicineAnti-inflammatoryAnginaPoster Presentationmedicinebusinessmedicine.drugdescription
Because of its ability to block late INa [1], ranolazine is used as an antianginal agent for the treatment of chronic angina pectoris when angina is not adequately controlled by other agents [2]. Besides its cardiovascular effects, ranolazine improves different neuronal functions, and thus its use has been proposed for the treatment of pain and epileptic disorders [3,4]. Since astrocytes are involved in neuronal inflammatory processes, and autoimmune and neurodegenerative diseases [5], we have investigated the antiinflammatory and antioxidant effects of ranolazine in primary cultured astrocytes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-03-01 | Critical Care |