0000000000807699

AUTHOR

Andreas Warnke

showing 8 related works from this author

Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder

2010

Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the…

Malemedicine.medical_specialtyCandidate geneAdolescentMedizinSocial SciencesGenome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideArticleGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciences0302 clinical medicinePerception and Action [DCN 1]Developmental and Educational PsychologymedicineIMPUTATIONAttention deficit hyperactivity disorderddc:61Humansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersInternational HapMap ProjectPsychiatryChildGenetic Association Studies030304 developmental biologyGenetic associationMental Health [NCEBP 9]0303 health sciencesCOMPONENTSmedicine.disease3. Good healthPREVALENCEPsychiatry and Mental healthAttention Deficit Disorder with HyperactivityMeta-analysisChild PreschoolFemalePsychologyFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryImputation (genetics)Clinical psychologyGenome-Wide Association Study
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Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in a randomized trial

2018

Abstract Background The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Methods The analysis included 143 mothers and children (aged 6–12 years) both diagnosed with ADHD. The study design was a two-stage, two-arm parallel group trial (Step 1 treatment group [TG]: …

AdultMalePediatricsmedicine.medical_specialtyEfficacylcsh:RC435-571610Motherslaw.inventionTreatment and control groups03 medical and health sciences0302 clinical medicinePharmacotherapy610 Medical sciences MedicineRandomized controlled trialChild of Impaired ParentslawIntervention (counseling)lcsh:PsychiatryMedicineHumans0501 psychology and cognitive sciencesddc:610ChildChildrenProblem BehaviorPsychiatric Status Rating ScalesPsychotropic Drugsbusiness.industryParent training05 social sciencesTreatment phasesAdult treatmentSequential treatmentCombined Modality Therapy3. Good healthPsychotherapyPsychiatry and Mental healthTreatment OutcomeAttention Deficit Disorder with HyperactivityParent trainingParental psychopathologyFemalebusiness030217 neurology & neurosurgery050104 developmental & child psychologyResearch Article
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A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an e…

2018

Abstract. Objective: We examined predictors and moderators of treatment outcome in mothers and children diagnosed with ADHD in a large multicentre RCT. Method: In total, 144 mother-child dyads with ADHD were randomly assigned to either a maternal ADHD treatment (group psychotherapy and open methylphenidate medication, TG) or to a control treatment (individual counselling without psycho- or pharmacotherapy, CG). After maternal ADHD treatment, parent-child training (PCT) for all mother-child dyads was added. The final analysis set was based on 123 dyads with completed primary outcome assessments (TG: n = 67, CG: n = 56). The primary outcome was the change in each child’s externalizing sympto…

Treatment outcomeMotherslaw.inventionTrans generationalRandomized controlled trialChild of Impaired Parentslawmental disordersmedicineAttention deficit hyperactivity disorderHumans0501 psychology and cognitive sciencesChildbusiness.industry05 social sciencesGeneral MedicineExploratory analysismedicine.diseaseModerationPrognosis3. Good healthPsychiatry and Mental healthClinical PsychologyTreatment OutcomeAttention Deficit Disorder with HyperactivityPediatrics Perinatology and Child HealthMethylphenidatePsychotherapy GroupFemalebusiness050104 developmental & child psychologyClinical psychologyZeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
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Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

2015

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 …

Nonsynonymous substitutionCandidate genemedicine.medical_specialtyShort CommunicationGenomicsS100 Calcium Binding Protein beta SubunitBiologyPolymorphism Single NucleotideDyslexia03 medical and health sciences0302 clinical medicineDCDC2Molecular geneticssingle-nucleotide polymorphismsmedicineHumansGenetic Predisposition to DiseasegeneticsGenotypingGenetic Association StudiesGenetics (clinical)ta515030304 developmental biologyGenetics0303 health sciencesperinnöllisyystiedeta1184DyslexiaSequence Analysis DNAmedicine.diseasedevelopmental dyslexiata3124Genetic epidemiologyCase-Control Studiesindividual genotypingMicrotubule-Associated Proteins030217 neurology & neurosurgeryJournal of Human Genetics
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A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.

2007

DYX3, a locus for dyslexia, resides on chromosome 2p11-p15. We have refined its location on 2p12 to a 157 kb region in two rounds of linkage disequilibrium (LD) mapping in a set of Finnish families. The observed association was replicated in an independent set of 251 German families. Two overlapping risk haplotypes spanning 16 kb were identified in both sample sets separately as well as in a joint analysis. In the German sample set, the odds ratio for the most significantly associated haplotype increased with dyslexia severity from 2.2 to 5.2. The risk haplotypes are located in an intergenic region between FLJ13391 and MRPL19/C2ORF3. As no novel genes could be cloned from this region, we hy…

MaleRibosomal ProteinsCandidate geneLinkage disequilibriumHeterozygoteTranscription GeneticLocus (genetics)BiologyPolymorphism Single NucleotideLinkage DisequilibriumDyslexiaEvolution MolecularMitochondrial Proteins03 medical and health sciences0302 clinical medicineIntergenic regionGene mappingDCDC2GermanyGeneticsmedicineAnimalsHumansFamilyMolecular BiologyGenetics (clinical)FinlandPhylogeny030304 developmental biologyGenetics0303 health sciencesHaplotypeDyslexiaBrainChromosome MappingGeneral Medicinemedicine.diseaseRepressor ProteinsPhenotypeHaplotypesChromosomes Human Pair 2Female030217 neurology & neurosurgeryHuman molecular genetics
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Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder

2008

Contains fulltext : 69243.pdf (Publisher’s version ) (Closed access) Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(S…

Genetics and epigenetic pathways of disease [NCMLS 6]Genetic LinkageEuropean Continental Ancestry GroupMedizinGenome ScanBiologyNeuroinformatics [DCN 3]Mental health [NCEBP 9]Genetic determinismWhite PeopleArticleChromosomesGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineGene mappingCognitive neurosciences [UMCN 3.2]Genetic linkageGenetic predispositionmedicinePerception and Action [DCN 1]Attention deficit hyperactivity disorderHumansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersGenetics (clinical)030304 developmental biologyProbabilityLinkage (software)Genetics0303 health sciencesGenomeGenome HumanPair 16Chromosome Mappingmedicine.diseasePsychiatry and Mental healthGenetic defects of metabolism [UMCN 5.1]Attention Deficit Disorder with HyperactivityMeta-analysisLod ScoreFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryChromosomes Human Pair 16HumanAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
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Does intensive multimodal treatment for maternal ADHD improve the efficacy of parent training for children with ADHD? A randomized controlled multice…

2015

Background This is the first randomized controlled multicenter trial to evaluate the effect of two treatments of maternal attention-deficit hyperactivity disorder (ADHD) on response to parent–child training targeting children's external psychopathology. Methods Mother–child dyads (n = 144; ADHD according to DSM-IV; children: 73.5% males, mean age 9.4 years) from five specialized university outpatient units in Germany were centrally randomized to multimodal maternal ADHD treatment [group psychotherapy plus open methylphenidate medication; treatment group (TG): n = 77] or to clinical management [supportive counseling without psychotherapy or psychopharmacotherapy; control group (CG): n = 67].…

AdultMalePediatricsmedicine.medical_specialtymedicine.medical_treatmentMothersChild Behavior DisordersGroup psychotherapyMaintenance therapyMulticenter trialOutcome Assessment Health CareDevelopmental and Educational PsychologymedicineHumansChildAdverse effectMethylphenidateMiddle AgedCombined Modality TherapyConfidence intervalPsychiatry and Mental healthAttention Deficit Disorder with HyperactivityPediatrics Perinatology and Child HealthMethylphenidatePsychotherapy GroupParent trainingCentral Nervous System StimulantsFamily TherapyFemalePsychologyPsychopathologymedicine.drugClinical psychologyJournal of Child Psychology and Psychiatry
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Additional file 1: of Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in …

2018

This article is accompanied by an online supplement containing additional information regarding the analysis. (PDF 376 kb)

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