0000000000954763
AUTHOR
C. Viñas
showing 16 related works from this author
Prediction of cardiovascular disease by the framingham-REGICOR equation in the high-risk PREDIMED cohort: Impact of the mediterranean diet across dif…
2017
Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major …
Synthesis of small carboranylsilane dendrons as scaffolds for multiple functionalizations.
2006
Small carbosilane dendrons in which a closo-carborane is located at the focal point have been prepared by a sequence of steps involving hydrosilylation and reduction reactions. These compounds are used as scaffolds for peripheral functionalization with styrene, chlorovinylstyrene, or suitable carboranes, while keeping the C(cluster)-Si (C(c)-Si) bond. Modification of the core by reduction of the carborane with Mg/BrCH2CH2Br was also achieved.
Synthesis of Boron-Iodinated o-Carborane Derivatives. Water Stability of the Periodinated Monoprotic Salt
2006
Boron periodination of o-carborane has been achieved by taking account of the fact that B atoms in the cluster are of two types, i.e., those adjacent to both C atoms and the remainder. The high number of nonequivalent leaving groups opens the possibility through B-C coupling to materials with novel possibilities and to self-assembling due to the enhanced polarizability of the C-H bond. Periodination has accentuated the acidity of the carborane, and monoprotic salts are stable in water.
Modular Construction of Neutral and Anionic Carboranyl-Containing Carbosilane-Based Dendrimers
2007
A modular construction of new carbosilane dendrimers, which contain four and eight peripheral carborane derivatives and propyl linkages between the C cluster and the Si atoms, has been developed using different methodologies. Regiospecific hydrosilylation of 1-C 6 H 5 -2-(CH 2 CH=CH 2 )-1,2-closo-C 2 B 10 H 10 (1) and 1-CH 3 -2-(CH 2 CH=CH 2 )-1,2-closo-C 2 B 10 H 10 (2) offers an efficient route to molecular precursors and building blocks that can provide both divergent and convergent strategies for dendritic growth. First generations of neutral carboranyl-containing dendrimers were constructed by two approaches: (a) a divergent approach via hydrosilylation of 1 and 2 with the first genera…
Formation of New η5-Rhodium(III) Complexes from η5-Rh(I) Rhodacarborane-Containing Charge-Compensated Ligands
2004
A series of new Rh(I) half-sandwich complexes of formula [3,3-(PPh 3 ) 2 -8-L-closo-3,1,2-RhC 2 B 9 H 1 0 )] (L = SMe 2 (2a), SEt 2 (2b), S(CH 2 ) 4 (2c), SEtPh (2d)) and [1-Me-3,3-(PPh 3 ) 2 -8-L-closo-3,1,2-RhC 2 B 9 H 9 )] (L = SMe 2 (2e), SEt 2 (2f)) have been prepared by reaction of the respective monoanionic charge-compensated ligands [10-L-nido-7,8-C 2 B 9 H 1 0 ] - and [7-Me-10-L-7,8-C 2 B 9 H 9 ] - with [RhCl(PPh 3 ) 3 ]. Complex [3,3-(cod)-8-SMe2-closo-3,1,2-RhC 2 B 9 H 1 0 ] (3) has also been prepared by reaction of K[10-SMe 2 -nido-7,8-C 2 B 9 H 1 0 ] with [RhCl(cod)] 2 . Rh(I) complexes 2a-d may be easily oxidized to the corresponding Rh(III) complexes 4a-d under N 2 atmosphere…
Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
2018
Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without ty…
Carboranyl Substituted Siloxanes and Octasilsesquioxanes: Synthesis, Characterization, and Reactivity
2008
Carboranyl-containing disiloxane, cyclic-siloxane and cage-like silsesquioxane have been prepared in high yields. Two routes are compared for their preparation, a classical hydrolytic process based on hydrolysis and condensation of the freshly prepared carboranylalkylchlorosilane and ethoxysilane precursors and a nonhydrolytic route based on the specific reactivity of chorosilane toward DMSO. Based on the typical reactivity of the carboranyl group toward nucleophiles, dianionic disiloxanes and octaanionic silsesquioxanes were obtained without modification of the siloxane bond. Products are fully characterized by FTIR, NMR and MALDI-TOF methods.
Approaches to the preparation of carborane-containing carbosilane compounds.
2005
[Structure: see text] A novel type of carborane cluster assembly has been successfully prepared using carbosilane derivatives as a scaffold. Two synthetic routes have been used: One involves the reaction of a carbosilane containing terminal Si-Cl functions with the lithium salt of the phenyl-o-carborane, and the second one consists of a highly efficient hydrosilylation of tetravinylsilane with the corresponding carboranylsilane. The crystal structure of this carborane-containing carbosilane compound has been determined by X-ray diffraction.
Formation of Bridging Alkene and Conjugated Dialkenes Exclusively Generated from Alkynes on the [3,3‘-Co(1,2-C2B9H11)2]- Platform. The Unique Hydrobo…
2003
The unprecedented metal-mediated transformation of an alkyne into a B,B' bridging alkene is reported. Also, the unprecedented synthesis of a conjugated dialkene derivative of [3,3'-Co(1,2-C2B9H11)2]- generated only from an alkyne, contrary to the usual case where an alkyne and an alkene are needed, is described. This has been possible through the singular capacity of a B-H to produce hydroboration.
Designed Synthesis of New ortho-Carborane Derivatives: from Mono- to Polysubstituted Frameworks
2008
The use of nucleophilic and electrophilic processes allow the designed synthesis of several B-iodinated derivatives of o-carborane. Because of the straightforward Pd-catalyzed conversion of B-I to B-C bond with Grignard reagents, such as methylMgBr and biPhenylMgBr, both, symmetrical 3,6-R 2-1,2- closo-C 2B 10H 10 and asymmetrical 3-I-6-Me-1,2- closo-C 2B 10H 10 could be obtained. Not only conventional reactions in solution have been studied but also a highly efficient, clean and fast solvent-free procedure has provided successful results to regioselectively produce B-iodinated o-carborane derivatives by a careful control of the reaction conditions. The high number of nonequivalent leaving …
Methylation and Demethylation in Cobaltabis(dicarbollide) Derivatives
2003
B(8)−R and B(8‘)−R (R = alkyl) disubstituted derivatives of the cobaltabis(dicarbollide) anion [3,3‘-Co(C2B9H11)2]- are reported. The synthesis was achieved by application of a modified Kumada reac...
Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies
2019
[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts.
Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults
2017
5 Tablas
Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta ME…
2016
12 Páginas.-- 6 Tablas.-- 1 Figura
CCDC 889022: Experimental Crystal Structure Determination
2015
Related Article: A. R. Popescu, I. Rojo, F. Teixidor, R. Sillanpää, C. Viñas|2015|Chem.-Eur.J.|21|8613|doi:10.1002/chem.201500307
CCDC 889025: Experimental Crystal Structure Determination
2015
Related Article: A. R. Popescu, I. Rojo, F. Teixidor, R. Sillanpää, C. Viñas|2015|Chem.-Eur.J.|21|8613|doi:10.1002/chem.201500307