Polymorphonuclear leukocyte membrane fluidity and cytosolic Ca2+ content at baseline and after activation in essential hypertension

THE DESIGN OF AN INFRASTRUCTURE FOR TECHNOLOGY TRANSFER IN SOUTHERN ITALY– ROLE OF REGIONAL INSTITUTIONS

This paper coordinates and integrates the interventions of Proff. G. LO GIUDICE and A. ROMANO, included in the conference programme. It starts mainly from the socio-economical system of Southern Italy, and it consists in the following main points: - analysis of the system features to be interconnected for the development of an infrastructure for developing technological transfer; - ways of understanding the suitability of technologies for Southern Italy; - a proposal for a macro-organizational model for the development of an infrastructure aiming at the technological transfer; - pointing out the role of the “Regioni” and of the direct Government interventions in the innovative processes. (I…

Search for heavy neutrinos at the NA48/2 and NA62 experiments at CERN

© The Authors, published by EDP Sciences. The NA48/2 experiment at CERN has collected large samples of charged kaons decaying into a pion and two muons for the search of heavy nuetrinos. In addition, its successor NA62 has set new limits on the rate of charged kaon decay into a heavy neutral lepton (HNL) and a lepton, with = e, µ, using the data collected in 2007 and 2015. New limits on heavy neutrinos from kaon decays into pions, muons and positrons are presented in this report.

Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging dat…

Neuroimmaging in childhood central nervous system tuberculosis

Infezione da HHV8 e leucemia linfoblastica acuta in età pediatrica

HHV8 è un virus erpetico correlato, sulla base di dati ormai concordi, al sarcoma di Kaposi (KS), al linfoma effusivo primario ed alla Ma- lattia di Castleman multicentrica. Tale virus è stato inoltre associato con altre patologie tumorali ma gli studi in proposito non sono stati confermati. Poco, d’altra parte, si conosce sulle modalità prevalenti di trasmissione del virus, probabilmente diverse nelle nazioni industrializzate ed in quelle in via di sviluppo. In Sicilia una elevata prevalenza del KS clas- sico era già presente in epoca pre-AIDS. Abbiamo condotto uno studio sierologico in immunofluorescenza per rilevare gli anticorpi anti-HHV8 in 40 bambini con leucemia linfoblastica acuta (…

Lower apoptosis rate in human cumulus cells, after r-LH administration in ovarian stimulation for IVF procedure

WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 – Area 5)

The Design of an Infrastructure for Technology Transfer in Southern Italy - Role of Regional Institutions

Abstract This paper coordinates and integrates the interventions of Proff. G. LO GIUDICE and A. ROMANO, included in the conference programme. It starts mainly from the socio-economical system of Southern Italy, and it consists in the following main points: - analysis of the system features to be interconnected for the development of an infrastructure for developing technological transfer; - ways of understanding the suitability of technologies for Southern Italy; - a proposal for a macro-organizational model for the development of an infrastructure aiming at the technological transfer; - pointing out the role of the”Regioni” and of the direct Government interventions in the innovative proce…

Searches for lepton number violating $K^+$ decays

The NA62 experiment at CERN reports a search for the lepton number violating decays K+ -> pi(-)e(+)e(+) and K+ -> pi(-)mu(+)mu(+) using a data sample collected in 2017. No signals are observed, and upper limits on the branching fractions of these decays of 2.2 x 10(-10) and 4.2 x 10(-11) are obtained, respectively, at 90% confidence level. These upper limits improve on previously reported measurements by factors of 3 and 2, respectively.

Search for heavy neutrinos in K + → μ + ν μ decays

The NA62 experiment recorded a large sample of K+→μ+νμ decays in 2007. A peak search has been performed in the reconstructed missing mass spectrum. In the absence of a signal, limits in the range 2×10−6 to 10−5 have been set on the squared mixing matrix element |Uμ4|2 between muon and heavy neutrino states, for heavy neutrino masses in the range 300–375 MeV/ c2 . The result extends the range of masses for which upper limits have been set on the value of |Uμ4|2 in previous production search experiments.

Tuberculosis of the central nervous system in children: 32 years survey.

Aim. In order to study the impact of clinical and diagnostic parameters on the clinical outcome of children with central nervous system tuberculosis (CNS-TB), we retrospectively reviewed all cases of CNS-TB diagnosed over a 32-year period at the Children's Hospital of Palermo, Italy. Methods. Data were collected with regard to the clinical, laboratory and demographic characteristics of patients, as well as the results of radiological investigations and data on clinical outcome. In relation to the date of introduction of new diagnostic methods (indirect as well direct) and to the change of treatment periods, the authors compared the clinical outcome of patients admitted prior and after 1984.…

Overview of the JET results

Since the installation of an ITER-like wall, the JET programme has focused on the consolidation of ITER design choices and the preparation for ITER operation, with a specific emphasis given to the bulk tungsten melt experiment, which has been crucial for the final decision on the material choice for the day-one tungsten divertor in ITER. Integrated scenarios have been progressed with the re-establishment of long-pulse, high-confinement H-modes by optimizing the magnetic configuration and the use of ICRH to avoid tungsten impurity accumulation. Stationary discharges with detached divertor conditions and small edge localized modes have been demonstrated by nitrogen seeding. The differences in…

Search for heavy neutral lepton production in K+ decays to positrons

A search for heavy neutral lepton ($N$) production in $K^+\to e^+N$ decays using the data sample collected by the NA62 experiment at CERN in 2017--2018 is reported. Upper limits of the extended neutrino mixing matrix element $|U_{e4}|^2$ are established at the level of $10^{-9}$ over most of the accessible heavy neutral lepton mass range 144--462 MeV/$c^2$, with the assumption that the lifetime exceeds 50 ns. These limits improve significantly upon those of previous production and decay searches. The $|U_{e4}|^2$ range favoured by Big Bang Nucleosynthesis is excluded up to a mass of about 340 MeV/$c^2$.

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Accepted Article

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

Apoptosis in Human Cumulus Cells

Search for K+→ π+νν¯ at NA62

Flavour physics is one of the most powerful fields for the search of new physics beyond the Standard Model. The kaon sector with the rare decay K+ → π+νν̅ provides one of the cleanest and most promising channels. NA62, a fixed target experiment at the CERN SPS, aims to measure BR (K+ → π+νν̅) with 10% precision to test the Standard Model validity up to an energy scale of hundreds of TeV. NA62 had dedicated data taking for the K+ → π+νν̅ measurement in 2016 and 2017 and will continue in 2018. Here preliminary results on a fraction of 2016 dataset are presented. The analysis of the complete 2016 data sample is expected to achieve the SM sensitivity.

NA48/62 latest results

The NA62 experiment at the CERN SPS recorded in 2007 a large sample of K+ ? µ+?µ decays. A peak search in the missing mass spectrum of this decay is performed. In the absence of observed signal, the limits obtained on B(K+ ? µ+?h) and on the mixing matrix element |Uµ 4| are reported. The upgraded NA62 experiment started data taking in 2015. About 5×1011K+ decays have been recorded so far to measure the branching ratio of the K+ ? ?+?? decay. Preliminary results from the K+ ? ?+?? analysis based on about 5% of the 2016 statistics are reported.

MOESM1 of Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Additional file 1. IPCRG scaling up activities.

Physics requirements for the VUV survey spectrometer intended for the divertor radiation monitoring on JT-60SA

JT-60SA is a fusion experiment designed to support the operation of ITER and to investigate how best to optimize the operation of future fusion power plants. For the safe operation of the device, a survey spectrometer observing the plasma from an equatorial port is foreseen to monitor light impurities such as carbon and oxygen, metal impurities and extrinsic impurities injected ad hoc to mitigate the power exhaust problem. A second survey spectrometer, to be designed and constructed within the presented work, positioned on an upper port with a vertical line of sight, will complement the monitoring activity of the first system by measuring the relative contribution of the various impurities …

Platelet activation markers in long-term follow-up of young subjects with acute myocardial infarction

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organizatio…

Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above. © 2016 Serdi and Springer-Verlag France

Simulation of the VUV spectral emission from the JT-60SA divertor

A divertor survey dual-spectrometer is being designed by an EU-Japan team [1] to be installed on JT-60SA [2], the new fusion experiment expected to start operating in 2020. Positioned on an upper port, the primary role of the spectrometer is to analyse the radiation losses in the divertor region and to aid studying the physics of the divertor plasmas, including plasma detachment. Its spatial resolution capability is around 10 cm at the divertor and its two branches together cover the wavelength range from 10 to 130 nm, to satisfy the physics scope [3]. The spectrometer Lines Of Sight (LOS) are mapped onto a 2D SOLEDGE [4] simulations of the divertor region carried out for different density …

Search for heavy neutral lepton production in K+ decays

A search for heavy neutral lepton production in $K^+$ decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015 is reported. Upper limits at the $10^{-7}$ to $10^{-6}$ level are established on the elements of the extended neutrino mixing matrix $|U_{\ell 4}|^2$ ($\ell=e,\mu$) for heavy neutral lepton mass in the range $170-448~{\rm MeV}/c^2$. This improves on the results from previous production searches in $K^+$ decays, setting more stringent limits and extending the mass range.

Polymorphonuclear leukocyte integrin pattern expression in atherosclerosis and diabetes

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care p…

Overview of the JET results with the ITER-like wall

Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Zeff (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. T…

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

AIMS: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. METHODS: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. STAKEHOLDERS: Incl…

Search for Lepton Number and Flavor Violation in K+ and π0 Decays

Searches for the lepton number violating $K^{+} \rightarrow \pi^{-} \mu^{+} e^{+}$ decay and the lepton flavour violating $K^{+} \rightarrow \pi^{+} \mu^{-} e^{+}$ and $\pi^{0} \rightarrow \mu^{-} e^{+}$ decays are reported using data collected by the NA62 experiment at CERN in $2017$-$2018$. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90% confidence level: $\mathcal{B}(K^{+}\rightarrow\pi^{-}\mu^{+}e^{+})<4.2\times 10^{-11}$, $\mathcal{B}(K^{+}\rightarrow\pi^{+}\mu^{-}e^{+})<6.6\times10^{-11}$ and $\mathcal{B}(\pi^{0}\rightarrow\mu^{-}e^{+})<3.2\times 10^{-10}$. These results improve by one order of magnitude over previous results for thes…

Study of the K±→π±γγ decay by the NA62 experiment

Abstract A study of the dynamics of the rare decay K ± → π ± γ γ has been performed on a sample of 232 decay candidates, with an estimated background of 17.4 ± 1.1 events, collected by the NA62 experiment at CERN in 2007. The results are combined with those from a measurement conducted by the NA48/2 Collaboration at CERN. The combined model-independent branching ratio in the kinematic range z = ( m γ γ / m K ) 2 > 0.2 is B MI ( z > 0.2 ) = ( 0.965 ± 0.063 ) × 10 − 6 , and the combined branching ratio in the full kinematic range assuming a Chiral Perturbation Theory description is B ( K π γ γ ) = ( 1.003 ± 0.056 ) × 10 − 6 . A detailed comparison of the results with the previous measurements…

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The …

Test of lepton flavour universality in K+→ℓ+ν decays

Abstract A precision test of lepton flavour universality has been performed by measuring the ratio R K of kaon leptonic decay rates K + → e + ν and K + → μ + ν in a sample of 59 813 reconstructed K + → e + ν candidates with ( 8.71 ± 0.24 ) % background contamination. The result R K = ( 2.487 ± 0.013 ) × 10 − 5 is in agreement with the Standard Model expectation.

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second c…

Diagnostic problems and postnatal follow-up in congenital toxoplasmosis

Aim. In order to assess the consequences of different clinica] approaches in the prenata] management of congenital toxoplasmosis, we retrospectively reviewed 58 pregnant women with Toxoplasma seroconversion and prospec­ tively enrolled their 59 infants, referred to us from 1999 to 2004. Metbods. Data on clinica!, laboratocy and de­ mographic characteristics of the pregnant women were collected. Their children were entered intoa 48-month follow-up progcamme in which clinica , instrumental, ophthalmo­ logic and serologic evaluations were carried out at birth, at 1, 3, 6, 9, 15, 18, 24, 36 and at 48 months of life. Paediatric treatment with Spiramycin alone or alternated with Pyrime­ thamine-S…

Precision measurement of the ratio of the charged kaon leptonic decay rates

A precision measurement of the ratio RK of the rates of kaon leptonic decays K+- --&gt; e nu and K+- --&gt; mu nu with the full data sample collected by the NA62 experiment at CERN in 2007-2008 is reported. The result, obtained by analysing ~150000 reconstructed K+- --&gt; e nu candidates with 11% background contamination, is RK = (2.488+-0.010)*10^{-5}, in agreement with the Standard Model expectation.