0000000001000583
AUTHOR
Daniel Gonzalez
showing 21 related works from this author
Measurement of the energy spectrum of cosmic rays above 10^18 eV using the Pierre Auger Observatory
2010
We report a measurement of the flux of cosmic rays with unprecedented precision and Statistics using the Pierre Auger Observatory Based on fluorescence observations in coincidence with at least one Surface detector we derive a spectrum for energies above 10(18) eV We also update the previously published energy spectrum obtained with the surface detector array The two spectra are combined addressing the systematic uncertainties and, in particular. the influence of the energy resolution on the spectral shape The spectrum can be described by a broken power law E-gamma with index gamma = 3 3 below the ankle which is measured at log(10)(E-ankle/eV) = 18 6 Above the ankle the spectrum is describe…
PRODIGE 59-DURIGAST trial: A randomised phase II study evaluating FOLFIRI + Durvalumab ± Tremelimumab in second-line of patients with advanced gastri…
2021
International audience; Gastric or gastro-oesophageal junction (GEJ) adenocarcinomas present poor overall survival (OS). First-line chemotherapy regimen for patients with HER2-negative tumours is based on a doublet or triplet of fluoropyrimidine plus platinum salt ± taxane. Second-line chemotherapy (Docetaxel or Irinotecan) improves OS which nonetheless remains poor (around 5 months). The first results of immune checkpoint inhibitors (anti-PD-1) combined with chemotherapy in metastatic gastric and GEJ cancers were discordant in recent phase III trials. Data on dual-blockade (anti-PD-L1 or anti-PD-1 plus anti-CTLA-4) plus chemotherapy are lacking. DURIGAST is a randomised, multicenter, non-c…
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG …
2017
Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE). Methods LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non…
Limit on the diffuse flux of ultrahigh energy tau neutrinos with the surface detector of the Pierre Auger Observatory
2009
Data collected at the Pierre Auger Observatory are used to establish an upper limit on the diffuse flux of tau neutrinos in the cosmic radiation. Earth-skimming ντ may interact in the Earth's crust and produce a τ lepton by means of charged-current interactions. The τ lepton may emerge from the Earth and decay in the atmosphere to produce a nearly horizontal shower with a typical signature, a persistent electromagnetic component even at very large atmospheric depths. The search procedure to select events induced by τ decays against the background of normal showers induced by cosmic rays is described. The method used to compute the exposure for a detector continuously growing with time is de…
Measurement of the Proton-Air Cross Section ats=57 TeVwith the Pierre Auger Observatory
2012
We report a measurement of the proton-air cross section for particle production at the center-of-mass energy per nucleon of 57 TeV. This is derived from the distribution of the depths of shower maxima observed with the Pierre Auger Observatory: systematic uncertainties are studied in detail. Analyzing the tail of the distribution of the shower maxima, a proton-air cross section of [505 +/- 22(stat)(-36)(+28)(syst)] mb is found.
The implication of OBP28a in Drosophila melanogaster chemosensory perception
2017
National audience; Chemoperception is critical for animals to detect nutritive food and avoid toxic compounds. As many other insects, Drosophila melanogaster uses various semiochemicals including pheromones and food volatiles to identify a suitable ecological niche and a mating partner. Chemosensory detection is mostly mediated by olfactory and gustatory systems involving several multigene chemoreceptor families. Volatile and non-volatile chemicals compounds entering into the sensory organ (sensillum) must be solubilized before being transported through the hydrophilic sensillum lymph bathing the chemosensory neurons. Such perireceptor events involve a family of soluble proteins named odora…
The Fluorescence Detector of the Pierre Auger Observatory
2010
The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It combines a surface array to measure secondary particles at ground level together with a fluorescence detector to measure the development of air showers in the atmosphere above the array. The fluorescence detector comprises 24 large telescopes specialized for measuring the nitrogen fluorescence caused by charged particles of cosmic ray air showers. In this paper we describe the components of the fluorescence detector including its optical system, the design of the camera, the electronics, and the systems for relative and absolute calibration. We also discuss the operation and the monitoring of the detecto…
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
2018
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…
A search for anisotropy in the arrival directions of ultra high energy cosmic rays recorded at the Pierre Auger Observatory
2012
Observations of cosmic ray arrival directions made with the Pierre Auger Observatory have previously provided evidence of anisotropy at the 99% CL using the correlation of ultra high energy cosmic rays (UHECRs) with objects drawn from the Véron-Cetty Véron catalog. In this paper we report on the use of three catalog independent methods to search for anisotropy. The 2pt–L, 2pt+ and 3pt methods, each giving a different measure of selfclustering in arrival directions, were tested on mock cosmic ray data sets to study the impacts of sample size and magnetic smearing on their results, accounting for both angular and energy resolutions. If the sources of UHECRs follow the same large scale structu…
Observation of the suppression of the flux of cosmic rays above 4x10^19eV
2008
The energy spectrum of cosmic rays above 2.5 × 10¹⁸ eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index γ of the particle flux, J ∝ E-γ, at energies between 4 × 10¹⁸ eV and 4 × 10¹⁹ eV is 2.69 ± 0.02(stat) ± 0.06(syst), steepening to 4.2 ± 0.4(stat) ± 0.06(syst) at higher energies. The hypothesis of a single power law is rejected with a significance greater than 6 standard deviations. The data are consistent with the prediction by Greisen and by Zatsepin and Kuz'min.
Update on the correlation of the highest energy cosmic rays with nearby extragalactic matter
2010
Data collected by the Pierre Auger Observatory through 31 August 2007 showed evidence for anisotropy in the arrival directions of cosmic rays above the Greisen-Zatsepin-Kuz'min energy threshold, 6 x 10(19) eV. The anisotropy was measured by the fraction of arrival directions that are less than 3.1 degrees from the position of an active galactic nucleus within 75 Mpc (using the Veron-Cetty and Veron 12th catalog). An updated measurement of this fraction is reported here using the arrival directions of cosmic rays recorded above the same energy threshold through 31 December 2009. The number of arrival directions has increased from 27 to 69, allowing a more precise measurement. The correlating…
Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to bitter molecules in food
2016
International audience
The exposure of the hybrid detector of the Pierre Auger Observatory
2010
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The ‘‘hybrid” detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data coll…
Atmospheric effects on extensive air showers observed with the Surface Detector of the Pierre Auger Observatory
2009
Atmospheric parameters, such as pressure (P), temperature (T) and density (ρ ∝ P/T), affect the development of extensive air showers initiated by energetic cosmic rays. We have studied the impact of atmospheric variations on extensive air showers by means of the surface detector of the Pierre Auger Observatory. The rate of events shows a ∼ 10% seasonal modulation and ∼ 2% diurnal one. We find that the observed behaviour is explained by a model including the effects associated with the variations of P and ρ. The former affects the longitudinal development of air showers while the latter influences the Molière radius and hence the lateral distribution of the shower particles. The model is val…
P45 - Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to bitter molecules in food
2016
International audience
Erratum to "Atmospheric effects on extensive air showers observed with the surface detector of the Pierre Auger observatory"[Astroparticle Physics 32…
2010
The Pierre Auger Collaboration... K.B. Barber... J.A. Bellido... R.W. Clay... B.R. Dawson... V.C. Holmes... J. Sorokin... P. Wahrlich... B.J. Whelan... M.G. Winnick... et al.
Structural and enzymatic characterization of a Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to …
2016
Glutathione transferases (GSTs) are ubiquitous key detoxification enzymes that catalyze the conjugation of glutathione to a large variety of xenobiotic chemical including odorants and sapid molecules. A previous study in Drosophila melanogaster demonstrated the existence of a GST specifically expressed in the antenna and involved in signal termination by catalyzing biotransformation of odorant molecules. Genomic analysis allows identifying forty GSTs in Drosophila melanogaster but their biochemistry is poorly documented. Here we demonstrated that among the GSTs, dmelGSTD2-2 was strongly and preferentially overexpressed in the sensory organs (antennae, proboscis, legs, wings) after an exposu…
Upper limit on the diffuse flux of ultrahigh energy tau neutrinos from the Pierre Auger Observatory
2008
The surface detector array of the Pierre Auger Observatory is sensitive to Earth-skimming tau neutrinos that interact in Earth’s crust. Tau leptons from ντ charged-current interactions can emerge and decay in the atmosphere to produce a nearly horizontal shower with a significant electromagnetic component. The data collected between 1 January 2004 and 31 August 2007 are used to place an upper limit on the diffuse flux of ντ at EeV energies. Assuming an E−2ν differential energy spectrum the limit set at 90% C.L. is E2νdNντdEν<1.3×10−7 GeV cm−2 s−1 sr−1 in the energy range 2×1017 eV<E<2×1019 eV.
Trigger and aperture of the surface detector array of the Pierre Auger Observatory
2010
The surface detector array of the Pierre Auger Observatory consists of 1600 water-Cherenkov detectors, for the study of extensive airshowers (EAS) generated by ultra-high-energy cosmic rays. We describe the trigger hierarchy, from the identification of candidates howers at the level of a single detector, amongst a large background (mainly random single cosmic ray muons), up to the selection of real events and the rejection of random coincidences. Such trigger makes the surface detector array fully efficient for the detection of EAS with energy above 3 x 1018 eV, for all zenith angles between 03 and 603, independently of the position of the impact point and of the mass of the primary particl…
Description of atmospheric conditions at the Pierre Auger Observatory using the Global Data Assimilation System (GDAS)
2012
Atmospheric conditions at the site of a cosmic ray observatory must be known for reconstructing observed extensive air showers. The Global Data Assimilation System (GDAS) is a global atmospheric model predicated on meteorological measurements and numerical weather predictions. GDAS provides altitude-dependent profiles of the main state variables of the atmosphere like temperature, pressure, and humidity. The original data and their application to the air shower reconstruction of the Pierre Auger Observatory are described. By comparisons with radiosonde and weather station measurements obtained on-site in Malargüe and averaged monthly models, the utility of the GDAS data is shown.
Correlation of the highest-energy cosmic rays with the positions of nearby active galactic nuclei
2008
Data collected by the Pierre Auger Observatory provide evidence for anisotropy in the arrival directions of the cosmic rays with the ighest-energies, which are correlated with the positions of relatively nearby active galactic nuclei (AGN) [Pierre Auger Collaboration, Science 318 (2007) 938]. The correlation has maximum significance for cosmic rays with energy greater than ~6 x 1019 eV and AGN at a distance less than ~75 Mpc. We have confirmed the anisotropy at a confidence level of more than 99% through a test with parameters specified a priori, using an independent data set. The observed correlation is compatible with the hypothesis that cosmic rays with the highest-energies originate fro…