0000000001024203

AUTHOR

F Perrone

showing 5 related works from this author

Quality of Life Analysis of TORCH, a Randomized Trial Testing First-Line Erlotinib Followed by Second-Line Cisplatin/Gemcitabine Chemotherapy in Adva…

2012

INTRODUCTION:: The TORCH (Tarceva or Chemotherapy) trial randomized patients with advanced non-small-cell lung cancer to first-line erlotinib followed by second-line cisplatin/gemcitabine versus. standard inverse sequence. The trial, designed to test noninferiority in overall survival, was stopped at interim analysis because of inferior survival in the experimental arm. Quality of life (QoL), a secondary outcome, is reported here. METHODS:: QoL was assessed at baseline and every 3 weeks during first-line, using European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 and QLQ-lung cancer specific module (LC13). Mean changes from baseline within arms …

OncologyMaleerlotinibLung NeoplasmsHealth-related quality of lifeNSCLCchemotherapyDeoxycytidinelaw.inventionRandomized controlled trialQuality of lifelawCarcinoma Non-Small-Cell LungSurveys and QuestionnairesAntineoplastic Combined Chemotherapy ProtocolsSurveys and QuestionnaireQuality of life analysis of TORCHErlotinib HydrochloridePrognosishumanitiesOncologyResearch DesignAdvanced non–small-cell lung cancerCarcinoma Squamous CellFemaleErlotinibRandomized trialmedicine.drugHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyPrognosiEGFRFirst-line treatmentfirst-line erlotinibsecond-line cisplatin/gemcitabine chemotherapyAdenocarcinomaNOFollow-Up StudieErlotinib HydrochlorideInternal medicineadvanced non-small-cell lung cancermedicineHumansLung cancerAdvanced non-small-cell lung cancer; Chemotherapy; EGFR; Erlotinib; First-line treatment; Health-related quality of life; Randomized trialQuality of life analysis of TORCH first-line erlotinib second-line cisplatin/gemcitabine chemotherapy advanced non-small-cell lung cancer.AgedNeoplasm StagingSalvage TherapyAntineoplastic Combined Chemotherapy Protocolbusiness.industryQuestionnaireCancerQuinazolinemedicine.diseaseInterim analysisGemcitabineGemcitabineSurgeryLung Neoplasmquality of lifeQuinazolinesCarcinoma Large CellCisplatinNeoplasm Recurrence LocalbusinessFollow-Up Studies
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Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung ca…

2005

Purpose To study the prognostic value for overall survival of baseline assessment of functional status, comorbidity, and quality of life (QoL) in elderly patients with advanced non—small-cell lung cancer treated with chemotherapy. Patients and Methods Data from 566 patients enrolled onto the phase III randomized Multicenter Italian Lung Cancer in the Elderly Study (MILES) study were analyzed. Functional status was measured as activities of daily living (ADL) and instrumental ADL (IADL). The presence of comorbidity was assessed with a checklist of 33 items; items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire QLQ-C30 (EORTC QLQ-C30) wer…

MaleCancer Researchmedicine.medical_specialtyLung NeoplasmsActivities of daily livingHealth StatuscarcinomaVinblastineVinorelbineDeoxycytidineolder peopleQuality of lifeInstrumental activitieCarcinoma Non-Small-Cell LungInternal medicineActivities of Daily LivingAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansLung cancerAgedAged 80 and overvalidationProportional hazards modelbusiness.industryQLQ-C30Age FactorsCancerVinorelbineclinical trialPrognosismedicine.diseaseGemcitabineComorbidityhumanitiescomorbidityOncologyQuartileQuality of LifePhysical therapyimpactGeriatric oncologyFemalebusinessRandomized-trialmedicine.drug
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The use of emergency laparoscopy for acute abdomen in the elderly: the FRAILESEL Italian Multicenter Prospective Cohort Study

2020

As the world population is aging rapidly, emergency abdominal surgery for acute abdomen in the elderly represents a global issue, both in developed and developing countries. Data regarding all the elderly patients who underwent emergency abdominal surgery from January 2017 to December 2017 at 36 Italian surgical departments were analyzed with the aim to appraise the contemporary reality regarding the use of emergency laparoscopy for acute abdomen in the elderly. 1993 patients were enrolled. 1369 (68.7%) patients were operated with an open technique; whereas, 624 (31.3%) underwent a laparoscopic operation. The postoperative morbidity rate was 32.6%, with a statically significant difference b…

MaleSettore MED/18 - CHIRURGIA GENERALEEndoscopy GastrointestinalCohort Studies0302 clinical medicinePostoperative ComplicationsElderlyAbdomen80 and overMedicineProspective StudiesProspective cohort studyLaparoscopyAbdomen AcuteAged 80 and overmedicine.diagnostic_testMortality rateAge FactorsPrognosisMulticenter studyItalyAcute abdomen030220 oncology & carcinogenesisEmergency surgery030211 gastroenterology & hepatologyFemalemedicine.symptomCohort studyRiskGastrointestinalmedicine.medical_specialtyAcuteMalignancyNOAcute abdomen03 medical and health sciencesEmergency surgeryHumansAgedbusiness.industryacute abdomen; elderly; emergency surgery; laparoscopy; multicenter studyEndoscopymedicine.diseaseSurgerySurgeryLaparoscopyEmergenciesMorbiditybusinessProcedures and Techniques UtilizationAbdominal surgery
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Risk factors for postoperative morbidity following appendectomy in the elderly: a nationwide prospective cohort study

2019

Background: A limited number of studies investigating perioperative risk factors associated with emergency appendectomy in elderly patients have been published to date. Whether older age may be associated with poorer outcomes following appendectomy is still a matter of debate. The primary aim of this study was to determine the predictors of postoperative morbidity following appendectomy in patients aged ≥ 65 years. Methods: Data regarding all elderly patients who underwent emergency appendectomy from January 2017 to June 2018 admitted 36 Italian surgical departments were prospectively collected and analyzed. Baseline demographics and perioperative variables were evaluated. Uni- and multivar…

medicine.medical_specialtyMultivariate analysisSports medicineSettore MED/18 - CHIRURGIA GENERALECritical Care and Intensive Care MedicineAcute appendicitis; Appendectomy; Elderly; Frail patients; Postoperative complicationsNOPostoperative complications03 medical and health scienceschemistry.chemical_compoundElderly0302 clinical medicineRisk FactorsAcute appendicitis Appendectomy Elderly Frail patients Postoperative complicationsInternal medicinemedicineHumansAppendectomyFrail patientOrthopedics and Sports MedicineIn patientProspective StudiesProspective cohort studyAgedRetrospective StudiesAcute appendicitis030222 orthopedicsCreatininebusiness.industryPostoperative complication030208 emergency & critical care medicinePerioperativeLength of StayAppendicitisPostoperative complicationchemistryEmergency MedicineLaparoscopySurgeryAcute appendicitiMorbidityRisk assessmentbusinessFrail patientsEuropean Journal of Trauma and Emergency Surgery
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PROGETTO DI CONSERVAZIONE E VALORIZZAZIONE DEL MEMORIALE ITALIANO DI AUSCHWITZ + PROGETTO GLOSSA 

2012

Nell’anniversario della liberazione del campo di sterminio di Auschwitz da parte dell'Armata rossa, in  quello che viene riconosciuto come Giorno della Memoria “al fine di ricordare tutti coloro la Shoah (sterminio del popolo  ebraico), le leggi razziali, la  persecuzione  italiana  dei  cittadini  ebrei,  gli  italiani che  hanno  subìto  la deportazione, la prigionia, la morte, nonché coloro che, anche in campi e schieramenti diversi, si sono opposti al progetto di sterminio, ed a rischio della propria vita hanno salvato altre vite e protetto i perseguitati.(legge 211 del 20 luglio 2000) l’arch. Peter Eisenman ha voluto essere a Milano per esprimere il suo supporto alla campagna per la co…

Settore L-ART/04 - Museologia E Critica Artistica E Del RestauroSettore ICAR/14 - Composizione Architettonica E UrbanaStato belle arti architettura New York Peter Eisenman dottorato Milano Brera Auschwitz Memoriale Italiano
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