6533b828fe1ef96bd12884ae

RESEARCH PRODUCT

Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study

P MaioneF PerroneC GalloL ManzioneF PiantedosiS BarberaS CigolariF RosettiE PiazzaSf RobbiatiO BertettoS NovelloMr MigliorinoA FavarettoM SpataforaF FerraùL FrontiniA BearzL RepettoC GridelliE BarlettaMl BarzelloniRv IaffaioliE De MaioM Di MaioG De FeoG SigorielloP ChiodiniA CioffiV GuardasoleV AngeliniA RossiD BilanciaD GermanoA LambertiV PontilloL BrancaccioF RendaF RomanoG EsaniA GambaroO VinanteG AzzarelloM ClericiR BollinaP BelloniM SannicolòL CiuffredaG ParelloM CabidduC SaccoA SibauG PorcileF CastiglioneO OstellinoS MonfardiniM StefaniG ScagliottiG SelvaggiF De MarinisO MartelliG GaspariniA MorabitoD GattusoG ColucciD GalettaF GiottaV GebbiaN BorsellinoA TestaE MalaponteMa CapuanoM AngiolilloF SollittoU TirelliS SpazzapanV AdamoG AltavillaA ScimoneMr HoppsF TartamellaGp IannielloV TinessaG FaillaR BordonaroN GebbiaMr ValerioM D'aprileE VeltriM TonatoS DarwishS RomitoF CarrozzaS BarniA ArdizzoiaGm CorradiniG PaviaM BelliG ColantuoniE GalligioniO CaffoR LabiancaA QuadriEnrico CortesiGiuliana D'auriaS FavaA CalcagnoG LuporiniMc LocatelliF Di CostanzoS GasperoniL IsaP CandidoF GaionG PalazzoloG NettisA AnnamariaM RinaldiM LopezR Felletti Di Negro GbN RossiA CalandrielloL MaiorinoR MattioliA CelanoS SchiavonA IllianoCa RaucciM CarusoP FoaG ToniniC CurcioM. Cazzaniga

subject

MaleCancer Researchmedicine.medical_specialtyLung NeoplasmsActivities of daily livingHealth StatuscarcinomaVinblastineVinorelbineDeoxycytidineolder peopleQuality of lifeInstrumental activitieCarcinoma Non-Small-Cell LungInternal medicineActivities of Daily LivingAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansLung cancerAgedAged 80 and overvalidationProportional hazards modelbusiness.industryQLQ-C30Age FactorsCancerVinorelbineclinical trialPrognosismedicine.diseaseGemcitabineComorbidityhumanitiescomorbidityOncologyQuartileQuality of LifePhysical therapyimpactGeriatric oncologyFemalebusinessRandomized-trialmedicine.drug

description

Purpose To study the prognostic value for overall survival of baseline assessment of functional status, comorbidity, and quality of life (QoL) in elderly patients with advanced non—small-cell lung cancer treated with chemotherapy. Patients and Methods Data from 566 patients enrolled onto the phase III randomized Multicenter Italian Lung Cancer in the Elderly Study (MILES) study were analyzed. Functional status was measured as activities of daily living (ADL) and instrumental ADL (IADL). The presence of comorbidity was assessed with a checklist of 33 items; items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire QLQ-C30 (EORTC QLQ-C30) were used to estimate QoL. ADL was dichotomized as none versus one or more dependency. For IADL and QoL, three categories were defined using first and third quartiles as cut points. Comorbidity was summarized using the Charlson scale. Analysis was performed by Cox model, and stratified by treatment arm. Results Better values of baseline QoL (P = .0003) and IADL (P = .04) were significantly associated with better prognosis, whereas ADL (P = .44) and Charlson score (P = .66) had no prognostic value. Performance status 2 (P = .006) and a higher number of metastatic sites (P = .02) also predicted shorter overall survival. Conclusions Pretreatment global QoL and IADL scores, but not ADL and comorbidity, have significant prognostic value for survival of elderly patients with advanced non—small-cell lung cancer who were treated with chemotherapy. Using these scores in clinical practice might improve prognostic prediction for treatment planning.

yearjournalcountryeditionlanguage
2005-01-01
10.1200/jco.2005.02.527http://hdl.handle.net/10447/9863