Synthesis of 8,9-dihydrodipyrazolo[3,4-b:4′,3′-f][1,5]diazocin-10(1H)-one. A new ring system

1995

8,9-Dihydrodipyrazolo[3,4-b:4′,3′-f][1,5]diazocin-10(1H)-ones 7 were prepared by cyclization of 1-ethyl-N,3-dimethyl-4-acetamido-N-(1-R1-3-R2-1H-pyrazol-5-yl)-1H-pyrazole-5-carboxamides 6 by a Bischler-Napieralski cyclization. A complete assignment of the chemical shifts to the carbon atoms of compound 7 was performed by different nmr experiments, such as DEPT and XHDEPT for onebond CH correlations and COLOC experiments for long-range C-H correlations.

Synthesis and COX inhibition of 7-R1-8-R2-1-ethyl-3,4-dimethyl-, 4,10-dihydro-1H-pyrazolo[3,4-c][1,5]benzodiazocine-5,11-diones

2008

The title compounds were easily synthesized by reacting the 4-aminopyrazole hydrochloride 2 and the substituted 2-nitrobenzoyl chlorides 3a-d. The obtained 2-nitrobenzamides 4a-d were methylated and then reduced to give the corresponding amines 6a-d. These were hydrolyzed then directly converted into 4,10-dihydro-1H-pyrazolo[3,4-c][1,5]benzodiazocine-5,11-diones 1a-d by the action of SOCl2 in benzene. These were tested for their COX inhibitory activity, showing an inhibitory profile against both COX-1 and COX-2, being slightly more selective against COX-2 with a percentage of inhibition, at the concentration of 10 μM, in the range 42.0 – 55.0.

Synthesis and spectroscopic characterizations of both 1-ethyl-4,8-dihydro-10-methoxy-3-methyl-8-r1-6-r2-dipyrazolo[3,4-b:4′,3′-f]-[1,5]diazocin-5(1H)…

1995

The non-selective methylation of compounds 3a-d using ethereal diazomethane, allowed the synthesis of isomers 4 and 5 which were useful intermediates for the preparation, by a simple approach, of the title compounds 7 and 9. A complete assignment of the chemical shifts to the carbon atoms of the compounds 7 and 9 was performed by different nmr experiments, such as DEPT and XHDEPT for onebond CH correlations and COLOC experiments for long-range C-H correlations.

Synthesis of a new bridgehead nitrogen heterocyclic system. Pyrrolo [2,1-f]-1,2,4-triazine derivatives

1979

1-Ureidopyrroles of type 6a,b prepared by the general method previously described (2), readily cyclized under basic conditions giving pyrrolo [2,1-f]-1,2,4-triazine-2,4(1H, 3H)dione derivatives.

ChemInform Abstract: Synthesis and Pharmacological Evaluation of 1-Methyl-5- [substituted-4(3H)-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic Aci…

2010

Abstract Several new 1-methyl-5-[substituted-4-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acids and their ethyl ester derivatives were prepared. The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effect, and as in vitro inhibitors of 3α-hydroxysteroid dehydrogenase (3α-HSD), since it is claimed that the inhibition of such an enzyme predicts in vivo antiinflammatory activity. Some compounds were more active than phenylbutazone in the phenylbenzoquinone and acetic acid peritonitis tests, and equiactive to the same drug in the carrageenin paw edema test. All the compounds inhibited the 3α-HSD, but no correlation was observed with the paw…

A facile synthesis of 1-ethyl-3-methyl-11-phenyl-1,4-dihydro-5H-pyrazolo[3,4-c][1,5]benzodiazocin-5-ones.A new ring system.

2007

Pyrazolobenzotriazinones Derivatives as COX Inhibitors: Synthesis Biological Activity and Molecular Modeling Studies

2010

Pyrazolylbenzotriazinones are endowed with structural analogy with the COX-2 selective inhibitor celecoxib. Considering that our research group has long been interested in the 3-pyrazolyl-substituted benzotriazinones as anti-inflammatory agents, six new pyrazolylbenzotriazinone derivatives 16a-c and 18a-c have been prepared by reacting the opportune ethyl 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate or 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxyic acid with sodium nitrite in glacial acetic acid. The biological studies revealed a good pharmacological profile for some pyrazolylbenzotriazinones and, in the case of the ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4H)-y…

Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine, a new ring system as potential COX inhibitor

2012

Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.

ChemInform Abstract: Synthesis of 8,9-Dihydrodipyrazolo(3,4-b:4′,3′-f) (1,5)diazocin-10(1H)- one. A New Ring System.

2010

8,9-Dihydrodipyrazolo[3,4-b:4′,3′-f][1,5]diazocin-10(1H)-ones 7 were prepared by cyclization of 1-ethyl-N,3-dimethyl-4-acetamido-N-(1-R1-3-R2-1H-pyrazol-5-yl)-1H-pyrazole-5-carboxamides 6 by a Bischler-Napieralski cyclization. A complete assignment of the chemical shifts to the carbon atoms of compound 7 was performed by different nmr experiments, such as DEPT and XHDEPT for onebond CH correlations and COLOC experiments for long-range C-H correlations.

ChemInform Abstract: Synthesis and Spectroscopic Characterizations of Both 1-Ethyl-4,8- dihydro-10-methoxy-3-methyl-8-R1-6-R2-dipyrazolo(3,4-b:4′,3′-…

2010

The non-selective methylation of compounds 3a-d using ethereal diazomethane, allowed the synthesis of isomers 4 and 5 which were useful intermediates for the preparation, by a simple approach, of the title compounds 7 and 9. A complete assignment of the chemical shifts to the carbon atoms of the compounds 7 and 9 was performed by different nmr experiments, such as DEPT and XHDEPT for onebond CH correlations and COLOC experiments for long-range C-H correlations.

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 7-SUBSTITUTED1-ETHYL-3,4,10-TRIMETHYL-1,10-DIHYDRO-11H-PYRAZOLO(3,4-c)(1,6)BENZODIAZOCIN-11-ONE: A NEW RI…

2004

Derivatives of the title ring system of type 10 were obtained in good yield by fusion of the intermediates 12. Attempt to cyclize the acetylamino derivative 9 under Bischler-Napieralski conditions failed because of the insufficient electronic density in the position 4 of the pyrazole ring created by the adjacent carbonyl moiety. The derivatives of the new ring system, assayed as anxiolytic agents, showed no significant activity.

Synthesis of a bridgehead nitrogen system. Imidazo[1,5-b]pyridazine derivatives

1979

3,4-Dibenzoyl-2-oxobutyrate 4-semicarbazone (6a), ethyl 2,4-dioxo-3-phenacylvalerate 3-semicarbazone (6b) and diethyl phenacyloxalectate 3-semicarbazone (6c) via acid catalysed intramolecular cyclization afforded 2-phenyl-4-R-3H-imidazo[1,5-d]pyridazine-5,7-(6H)diones (8d,e,f). Elemental analyses and spectroscopic data (ir, nmr, ms) were in good agreement with the assigned structures.

New synthesis of some 1,2,5-benzothiadiazcpinc 1,1-dioxide derivatives. I

1979

2-Nitrobenzenesulfonyl chloride reacts with ω-aminoacetophenone and 4-amino-3,5-dimethyl-isoxazole to give 3 and 7, respectively. Reduction of 3 with zinc powder and acetic acid afforded the 2,5-dihydro- and 2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine I,1-dioxide derivatives (4 and 5). Catalytic hydrogenolysis of 7 and successive cyclization of the intermediate 8 gave the 3-ace-thyl-2,5-dihydro-4-methyl-1,2,5-benzothiadiazepine 1,1-dioxide (9). The structures were assigned on the basis of correct elemental data and spectroscopic evidences.

Synthesis of I-Hydroxy-2,4-diphenylpyrrolo[2,3-d] pyridazin-7(6H)one

1979

Bei der Behandlung mit HCl in Methanol erhalt man aus dem Oxim (I) das Cyclisierungsprodukt, das mit Hydrazin weiter zu (III) kondensiert wird.

BENZOTRIAZINONE AND QUINAZOLINONE DERIVATIVES AS COX-INHIBITORS: COMPUTATIONAL STUDIES

2005

Synthesis and pharmacological evaluation of 1-methyl-5- [substituted-4(3H)-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acid derivatives

1998

Several new 1-methyl-5-[substituted-4-oxo-1,2,3-benzotriazin-3-yl] -1H-pyrazole-4-acetic acids and their ethyl ester derivatives were prepared. The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effect, and as in vitro inhibitors of 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), since it is claimed that the inhibition of such an enzyme predicts in vivo antiinflammatory activity. Some compounds were more active than phenylbutazone in the phenylbenzoquinone and acetic acid peritonitis tests, and equiactive to the same drug in the carrageenin paw edema test. All the compounds inhibited the 3 alpha-HSD, but no correlation was observed with …