0000000001299823
AUTHOR
Florian Chotard
showing 30 related works from this author
Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.
2018
Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effects; one displayed pro-inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two-photon microscopy.
Atom Transfer Radical Addition Catalyzed by Ruthenium–Arene Complexes Bearing a Hybrid Phosphine–Diene Ligand
2018
International audience; The synthesis and characterization of a series of arene ruthenium complexes bearing either (3,5-cycloheptadienyl)diphenylphosphine or (cycloheptyl)-diphenylphosphine are reported. Upon irradiation or heating, all these complexes lose their arene ligand but then exhibit a different behavior depending on the nature of the phosphine ligand. (Cycloheptadienyl)phosphine complexes 1 and 3 give a cationic dinuclear Ru complex 5 for which the two Ru atoms are bridged by three chlorido ligands and flanked by two tridendate (cycloheptadienyl)phosphines. (Cycloheptyl)-diphenylphosphine complexes 2 and 4 undergo arene exchange when toluene is used as solvent or degrade in dithlo…
Phenoxyamidine Zn and Al Complexes: Synthesis, Characterization, and Use in the Ring-Opening Polymerization of Lactide
2019
International audience; Herein we report the synthesis of new ditopic ligands, which consist of a phenoxy group and N,N,N'trisubstituted amidines linked by a methylene spacer (L1-L4). Their coordination chemistry has been studied/investigated with Zn(II) and Al(III). Alkane elimination route between the phenol-amidine proligands (L1H-L4H) and Et2Zn led to dinuclear complexes [(L1-L4)ZnEt]2 (1a-4a) in which the Zn centers are chelated by phenoxyamidine ligands and bridged through the oxygen atom of the phenoxy groups. Salt metathesis reaction between two equivalents of the sodium amidine phenate L1Na and ZnCl2 led to a bis-chelate chiral spiro-complex (L12Zn) 1a'. Analogous alkane eliminatio…
Assessment of Catalysis by Arene‐Ruthenium Complexes Containing Phosphane or NHC Groups bearing Pendant Conjugated Diene Systems
2015
Two p-cymene-ruthenium complexes 1 and 2 were isolated in high yields by treating the [RuCl2(p-cymene)]2 dimer with new hybrid phosphane- or NHC-linked diene ligands. Both complexes were fully characterized by NMR spectroscopy, and the molecular structure of the ruthenium–p-cymene complex 1, containing the phosphane–diene ligand system, was determined by X-ray diffraction analysis. The catalytic activities of both compounds were probed in atom-transfer radical addition (ATRA) and polymerization (ATRP), in the cyclopropanation of olefins, in the ring-opening metathesis polymerization (ROMP) of norbornene, and in the synthesis of enol esters from hex-1-yne and 4-acetoxybenzoic acid.
Highly antiproliferative neutral Ru(ii)-arene phosphine complexes
2018
Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.
Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a “Smart” Probe Answer!
2015
Gold phosphine complexes, such as auranofin, have been recognized for decades as antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or anti-HIV treatments. However, their mechanisms of action remain unclear. A challenging question is whether the gold phosphine complex is a prodrug that is administered in an inactive precursor form or rather that the gold atom remains attached to the phosphine ligand during treatment. In this study, we present two novel gold complexes, which we compared to auranofin and to their phosphonium analogue. The chosen ligand is a phosphine-based smart probe, whose strong fluorescence depends on the presence of the gold atom. …
Gold( i )–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents
2017
International audience; Two new gold(I)–BODIPY–imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.
Phosphine-diène and Salicylamidines ligands : coordination chemistry, catalysis and therapy
2017
The subject of this thesis concerns the development of new ligands, their coordination chemistry, and the synthesis of the corresponding metal complexes for catalysis and therapy.The first part of this work relates to the synthesis of diene-phosphine ligands, their saturated analogs, and the corresponding arene-ruthenium complexes. Arene decoordination allows the formation of a cationic bimetallic complex where the ligand is diène-η4/κ-P coordinated to the ruthenium. These complexes have been applied to atom transfer radical addition (ATRA) of CCl4 to styrene. When harsh reaction conditions are used, the superiority of the “diene” complexes is highlighted comparing to saturated analogs.The …
CCDC 1868748: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1578513: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1578514: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1828666: Experimental Crystal Structure Determination
2018
Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Philippe Richard, Ali Bettaïeb, Catherine Paul, Jean-Louis Connat, Pierre Le Gendre, Ewen Bodio|2018|ChemMedChem|13|2408|doi:10.1002/cmdc.201800474
CCDC 1868745: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1868749: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1828665: Experimental Crystal Structure Determination
2018
Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Philippe Richard, Ali Bettaïeb, Catherine Paul, Jean-Louis Connat, Pierre Le Gendre, Ewen Bodio|2018|ChemMedChem|13|2408|doi:10.1002/cmdc.201800474
CCDC 1578510: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1868747: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1937786: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1014822: Experimental Crystal Structure Determination
2015
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480
CCDC 1578511: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1538131: Experimental Crystal Structure Determination
2017
Related Article: Audrey Trommenschlager, Florian Chotard, Benoît Bertrand, Souheila Amor, Lucile Dondaine, Michel Picquet, Philippe Richard, Ali Bettaïeb, Pierre Le Gendre, Catherine Paul, Christine Goze, Ewen Bodio|2017|Dalton Trans.|46|8051|doi:10.1039/C7DT01377A
CCDC 1578512: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1014823: Experimental Crystal Structure Determination
2015
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480
CCDC 1868750: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1868746: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1868743: Experimental Crystal Structure Determination
2019
Related Article: Florian Chotard, Rosita Lapenta, Anaëlle Bolley, Audrey Trommenschlager, Cédric Balan, Jérôme Bayardon, Raluca Malacea-Kabbara, Quentin Bonnin, Ewen Bodio, Hélène Cattey, Philippe Richard, Stefano Milione, Alfonso Grassi, Samuel Dagorne, Pierre Le Gendre|2019|Organometallics|38|4147|doi:10.1021/acs.organomet.9b00501
CCDC 1056295: Experimental Crystal Structure Determination
2015
Related Article: Johann Baraut, Alexandre Massard, Florian Chotard, Ewen Bodio, Michel Picquet, Philippe Richard, Yannick Borguet, François Nicks, Albert Demonceau, Pierre Le Gendre|2015|Eur.J.Inorg.Chem.||2671|doi:10.1002/ejic.201500054
CCDC 1578509: Experimental Crystal Structure Determination
2018
Related Article: Florian Chotard, Raluca Malacea-Kabbara, Cédric Balan, Ewen Bodio, Michel Picquet, Philippe Richard, Miguel Ponce-Vargas, Paul Fleurat-Lessard, Pierre Le Gendre|2018|Organometallics|37|812|doi:10.1021/acs.organomet.7b00851
CCDC 1023384: Experimental Crystal Structure Determination
2015
Related Article: Johann Baraut, Alexandre Massard, Florian Chotard, Ewen Bodio, Michel Picquet, Philippe Richard, Yannick Borguet, François Nicks, Albert Demonceau, Pierre Le Gendre|2015|Eur.J.Inorg.Chem.||2671|doi:10.1002/ejic.201500054
CCDC 1014821: Experimental Crystal Structure Determination
2015
Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480