0000000001304024

AUTHOR

Göran Landberg

showing 8 related works from this author

N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

2015

Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cel…

kemiaToussaintia orientalismedicine.drug_classAntitubercular AgentsPharmaceutical ScienceAnnonaceaeMicrobial Sensitivity TestsAntimycobacterialchemistry01 natural sciencesHigh-performance liquid chromatographyTanzaniaAnalytical ChemistryMycobacterium tuberculosischemistry.chemical_compoundColumn chromatographyDrug DiscoverymedicineHumansTriple negativeNuclear Magnetic Resonance Biomolecularta116PharmacologyChromatographybiologyStrain (chemistry)Molecular Structure010405 organic chemistryCyclohexanonesOrganic ChemistryMycobacterium tuberculosisbiology.organism_classificationtoussaintia orientalis0104 chemical sciences3. Good healthPlant Leavesn-cinnamoyltetraketide010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryCinnamatesMolecular MedicineFemaleMethanolDrug Screening Assays AntitumorJournal of Natural Products
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Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei

2016

The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2'-binaphthralenyl-1,1'-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-base…

StereochemistryPlasmodium falciparumPharmaceutical SciencePentasAnthraquinonesRubiaceaeCrystallography X-Ray010402 general chemistryPlant Roots01 natural sciencesAnalytical ChemistryAntimalarialsInhibitory Concentration 50chemistry.chemical_compoundBreast cancer cell lineDrug DiscoveryAnthraquinonesIc50 valuesHumansNuclear Magnetic Resonance Biomolecularta116naphthalene derivativesNaphthalenenaphthalenesPharmacologyPentasMolecular Structurebiology010405 organic chemistryOrganic Chemistryta1182Pentas parvifoliabiology.organism_classificationphytochemicals0104 chemical sciencesComplementary and alternative medicinechemistryPhytochemicalMolecular MedicineJournal of Natural Products
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Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.

2015

Five new compounds, 4-O-geranylisoliquiritigenin (1), 12-dihydrousararotenoid B (2), 12-dihydrousararotenoid C (3), 4'-O-geranyl-7-hydroxyflavanone (4), and 4'-O-geranyl-7-hydroxydihydroflavanol (5), along with 12 known natural products (6-17) were isolated from the CH2Cl2/MeOH (1:1) extract of the root bark of Millettia usaramensis ssp. usaramensis by chromatographic separation. The purified metabolites were identified by NMR spectroscopic and mass spectrometric analyses, whereas their absolute configurations were established on the basis of chiroptical data and in some cases also by X-ray crystallography. The crude extract was moderately active (IC50 = 11.63 μg/mL) against the ER-negative…

StereochemistryPlasmodium falciparumMolecular ConformationPharmaceutical Scienceroot barkCrystallography X-Ray01 natural sciencesMillettiaAnalytical ChemistryMillettia usaramensischemistry.chemical_compoundAntimalarialsChalconesDrug DiscoveryPlant BarkHumansta116IC50Nuclear Magnetic Resonance Biomolecularta317metabolitesPharmacologyFlavonoidsChromatographyNatural productbiologyMolecular Structure010405 organic chemistryChemistryPlant ExtractsOrganic ChemistryPlasmodium falciparumChloroquinebiology.organism_classification0104 chemical sciencesMillettia010404 medicinal & biomolecular chemistryChromatographic separationHEK293 CellsComplementary and alternative medicinevisual_artFlavanonesvisual_art.visual_art_mediumPlant BarkMolecular MedicineBarkrotenoidsJournal of natural products
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CCDC 1409159: Experimental Crystal Structure Determination

2016

Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters11b-Hydroxy-4a11b-dihydro[13]dioxolo[67]chromeno[34-b][13]dioxolo[45-h]chromen-12(5H)-oneExperimental 3D Coordinates
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CCDC 1061815: Experimental Crystal Structure Determination

2016

Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters12b-Hydroxy-22-dimethyl-5a12b-dihydro-2H-[13]dioxolo[67]chromeno[34-b]pyrano[23-h]chromen-13(6H)-oneExperimental 3D Coordinates
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CCDC 1452354: Experimental Crystal Structure Determination

2016

Related Article: Negera Abdissa, Fangfang Pan, Amra Gruhonjic, Jürgen Gräfenstein, Paul A. Fitzpatrick, Göran Landberg, Kari Rissanen, Abiy Yenesew, Máté Erdélyi|2016|J.Nat.Prod.|79|2181|doi:10.1021/acs.jnatprod.6b00178

9-hydroxy-212-dimethoxy-35a-dimethyl-233a455a12c12d-octahydro-16-dioxabenzo[l]acephenanthrylene-10-carboxylic acidSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1409160: Experimental Crystal Structure Determination

2016

Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581

4a5-Dihydro[13]dioxolo[67]chromeno[34-b][13]dioxolo[45-h]chromene-11b12(12H)-diolSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1452353: Experimental Crystal Structure Determination

2016

Related Article: Negera Abdissa, Fangfang Pan, Amra Gruhonjic, Jürgen Gräfenstein, Paul A. Fitzpatrick, Göran Landberg, Kari Rissanen, Abiy Yenesew, Máté Erdélyi|2016|J.Nat.Prod.|79|2181|doi:10.1021/acs.jnatprod.6b00178

Space GroupCrystallographyCrystal System2-ethoxy-9-hydroxy-12-methoxy-35a-dimethyl-233a455a12c12d-octahydro-16-dioxabenzo[l]acephenanthrylene-10-carboxylic acidCrystal StructureCell ParametersExperimental 3D Coordinates
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