0000000001304093
AUTHOR
Riikka Kuosmanen
Stimuli-responsive bile acid-based metallogels forming in aqueous media
Abstract The synthesis and gelation properties of a picolinic acid conjugated bile acid derivative in the presence of metal salts along with the stimuli-responsiveness of the systems are reported. The gels are formed in the presence of Cu 2+ ions in the solvent systems composed of 30–50% of organic solvent (MeOH, acetonitrile, or acetone) in water. The gels respond to various stimuli: they can be formed upon sonication or shaking, and their gel–sol transformation can be triggered by a variety of chemical species. NMR, MS, and SEM techniques are exploited in order to gain a deeper insight on the self-assembled systems.
Steroidal supramolecular metallogels
The review deals with an expanding number of steroidal compounds that are capable of forming a metallogel providing a multitude of novel materials rich in their properties. The future of steroidal metallogels holds a myriad of potential applications as new intelligent materials. Detection of potentially harmful compounds without expensive instrumentation, entrapment of environmentally hazardous substances, and sensitive and selective nanomaterials represent only a few of these potential applications. This article reviews the design, synthesis, characterization, and applications of steroidal metallogels. peerReviewed
Systematic Modulation of the Supramolecular Gelation Properties of Bile Acid Alkyl Amides
The self-assembly properties of nine low-molecular-weight gelators (LMWGs) based on bile acid alkyl amides were studied in detail. Based on the results, the number of hydroxyl groups attached to the steroidal backbone plays a major role in the gelation, although the nature of the aliphatic side chain also modulates the gelation abilities. Of the 50 gel systems studied, 35 are based on lithocholic acid and 15 on cholic acid derivatives. The deoxycholic acid derivatives did not form any gels. The gelation occurred primarily in aromatic solvents and the gels manifested typical fibrous or spherical morphologies. The 13C cross-polarized magic angle spinning (CPMAS) NMR spectra measured on the cr…
Biocompatible Hydrogelators Based on Bile Acid Ethyl Amides
Four novel bile acid ethyl amides were synthetized using a well-known method. All the four compounds were characterized by IR, SEM, and X-ray crystal analyses. In addition, the cytotoxicity of the compounds was tested. Two of the prepared compounds formed organogels. Lithocholic acid derivative 1 formed hydrogels as 1% and 2% (w/v) in four different aqueous solutions. This is very intriguing regarding possible uses in biomedicine. peerReviewed
CCDC 1550984: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550980: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550979: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550977: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550981: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550982: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1438665: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Roosa-Maria Willman, Ilkka Aijalainen, Jitka Ulrichova, Adela Galandakova, Hannu Salo, Kari Rissanen and Elina Sievänen|2016|Steroids|108|7|doi:10.1016/j.steroids.2016.02.014
CCDC 1550978: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1438667: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Roosa-Maria Willman, Ilkka Aijalainen, Jitka Ulrichova, Adela Galandakova, Hannu Salo, Kari Rissanen and Elina Sievänen|2016|Steroids|108|7|doi:10.1016/j.steroids.2016.02.014
CCDC 1438666: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Roosa-Maria Willman, Ilkka Aijalainen, Jitka Ulrichova, Adela Galandakova, Hannu Salo, Kari Rissanen and Elina Sievänen|2016|Steroids|108|7|doi:10.1016/j.steroids.2016.02.014
CCDC 1550985: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151
CCDC 1550983: Experimental Crystal Structure Determination
Related Article: Riikka Kuosmanen, Rakesh Puttreddy, Kari Rissanen, Elina Sievänen|2018|Chem.-Eur.J.|24|18676|doi:10.1002/chem.201803151