6533b7cffe1ef96bd1258f1d
RESEARCH PRODUCT
Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection.
Rafael PovedaManuela Torres-puenteCarmen GavaldáTrinidad M. AlberolaCrispian ScullyYolanda JiménezManuel Pérez-alonsoJose V. BaganJudith Murillosubject
Pathologymedicine.medical_specialtyBiopsyHyperkeratosisAlphapapillomavirusVirusBiopsyCarcinomaMedicineHumansStage (cooking)LeukoplakiaAgedAged 80 and overmedicine.diagnostic_testbusiness.industryPapillomavirus InfectionsHPV infectionMouth MucosaMiddle Agedbacterial infections and mycosesmedicine.diseasestomatognathic diseasesOtorhinolaryngologyCarcinoma Squamous CellSurgeryFemaleMouth NeoplasmsViral diseaseOral SurgeryLeukoplakia Oralbusinessdescription
Purpose To analyze proliferative verrucous leukoplakia (PVL) for the presence of human papillomavirus (HPV) in different stages of the disease. Materials and Methods We studied 13 patients with PVL. In 10 patients (76.9%), a lesional biopsy was taken and frozen at −40°C. Four patients were instructed to mouth rinse with sterile sera. The biopsy and rinse samples were analyzed for HPV by PCR. Results We did not detect HPV infection in the PVL tissue or in the oral rinse of any of the 13 patients in any stage of the disease analyzed, neither in oral squamous cell carcinoma nor in the simple hyperkeratosis. Conclusion There was no association between PVL and HPV infection in our patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-04-14 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons |