Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene

6533b7cffe1ef96bd12590e7

RESEARCH PRODUCT

Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene–saturated fat interaction

José V. Sorlí José V. Sorlí S. K. Chew Antonio Garcia-rios Antonio Garcia-rios Ramon Estruch Ramon Estruch Dolores Corella O. Coltell O. Coltell E-shyong Tai Jose M. Ordovas Jose M. Ordovas Jose M. Ordovas Mercedes Sotos-prieto Mercedes Sotos-prieto

subject

Male Saturated fat saturated fat Genotype Endocrinology Diabetes and Metabolism Saturated fat Population Medicine (miscellaneous)Biology Polymorphism Single Nucleotide Mediterranean Basin Article White People APOA2 Body Mass Index Asian People Gene interaction insulin resistance Genotype gene-diet interaction medicine Humans Genetic Predisposition to Disease Obesity education Gene Alleles Aged Genetics education.field_of_study Nutrition and Dietetics Body Weight Insulin resistance medicine.disease Dietary Fats Obesity Cross-Sectional Studies Cardiovascular Diseases Gene–diet interaction Female Body mass index Apolipoprotein A-II

description

Objective: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2–saturated fat interaction determining body mass index (BMI) and obesity in American populations. This work aims to extend our findings to European and Asian populations. Methods: Cross-sectional study in 4602 subjects from two independent populations: a high-cardiovascular risk Mediterranean population (n=907 men and women; aged 67±6 years) and a multiethnic Asian population (n=2506 Chinese, n=605 Malays and n=494 Asian Indians; aged 39±12 years) participating in a Singapore National Health Survey. Anthropometric, clinical, biochemical, lifestyle and dietary variables were determined. Homeostasis model assessment of insulin resistance was used in Asians. We analyzed gene–diet interactions between the APOA2 −265T>C polymorphism and saturated fat intake (C polymorphism on body-weight-related measures was modulated by saturated fat in Mediterranean and Asian populations.

year	journal	country	edition	language
2011-05-01	International Journal of Obesity

https://doi.org/10.1038/ijo.2010.187