6533b7d0fe1ef96bd125b94a

RESEARCH PRODUCT

Steroid hormone receptors in human melanoma.

G. W. KortingB. MorschesKunhard PollowBernhard ManzP. BenesP. SchrammHans-jörg Grill

subject

Malemedicine.medical_specialtyReceptors SteroidSkin Neoplasmsmedicine.drug_classmedicine.medical_treatmentEstrogen receptorDermatologyBiologyCytosolReceptors GlucocorticoidSex FactorsInternal medicinemedicineCentrifugation Density GradientHumansReceptorMelanomaEstrogen receptor betaSignificant differenceGeneral MedicineSteroid hormoneEndocrinologyReceptors EstrogenEstrogenHuman melanomaFemaleReceptors Progesterone

description

Human melanomas were investigated for the presence of high-affinity estrogen-, gestagen-, and glucocorticoid-binding proteins. A statistically significant difference was found for mean estrogen receptor (ER) concentrations in melanomas of male versus female origin: female origin 37.6 (0-107) fmol/mg protein, male origin 3.9 (0-8.3) fmol/mg protein. No significant difference between sexes was found for gestragen receptors: 41.5 (0-194) fmol/mg protein for melanomas of female origin versus 99 (0-362) fmol/mg protein for male. Sucrose density gradient analyses revealed specific binding for both receptor types in the 4-5 S region as well as in the 8 S region. The binding affinities were in the same order of magnitude as reported for receptors found in typical steroid target organs. No significant difference in receptor values depending on sex was found for the glucocorticoid receptor: 19.2 (0-43) fmol/mg protein.

yearjournalcountryeditionlanguage
1981-01-01Archives of dermatological research
10.1007/bf00510399https://pubmed.ncbi.nlm.nih.gov/7165327