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RESEARCH PRODUCT
Unprecedented Palladium-Catalyzed Cross-Coupling Reaction of α-Bromo Sulfoxides with Boronic Acids
Carmen Ramírez De ArellanoAna B. CuencaNuria RodríguezGregorio AsensioMercedes Medio-simónsubject
inorganic chemicalsChemistryArylOrganic Chemistrychemistry.chemical_elementHalideGeneral MedicineBiochemistryOxidative additionOxygenCoupling reactionCatalysischemistry.chemical_compoundSuzuki reactionPolymer chemistryOrganic chemistryPhysical and Theoretical ChemistryPalladiumdescription
[reaction: see text] A new Suzuki-type palladium-catalyzed reaction of boronic acids with alpha-bromo sulfoxides has been developed using a protocol similar to the well-documented reaction of boronic acids with aryl halides. Both cross-coupling and homocoupling processes were observed. The best yields in cross-coupling products were obtained when the presence of oxygen was carefully excluded using degassed solvents. The oxidative addition palladium complex intermediate could be isolated and characterized by X-ray single-crystal diffraction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-04-12 | Organic Letters |