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RESEARCH PRODUCT
Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature
Giuseppe FerreraFrancesco CucciaGiuseppe CraparoG. MortellaroLucia OgnibeneAntonio Lo Castosubject
MaleRe-IrradiationCancer Researchmedicine.medical_specialtyAdult MedulloblastomaNauseamedicine.medical_treatmentDiseaseGeneral Biochemistry Genetics and Molecular BiologyRe-Irradiation03 medical and health sciences0302 clinical medicineRecurrent diseaseHumansMedicineEffective treatmentCerebellar NeoplasmsSalvage TherapyPharmacologyMedulloblastomaChemotherapybusiness.industryAdult patientsMiddle Agedmedicine.diseaseMagnetic Resonance ImagingTumor BurdenTreatment OutcomePositron-Emission Tomography030220 oncology & carcinogenesisRadiologymedicine.symptombusinessResearch ArticleMedulloblastomadescription
Background/aim Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series. Case report A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-05-03 | In Vivo |