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RESEARCH PRODUCT

Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study).

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Overweight and obesity have been steadily increasing in recent years and currently represent a serious threat to public health. Few human studies have investigated the relationship between polyphenol intake and body weight. Our aim was to assess the relationship between urinary polyphenol levels and body weight. A cross-sectional study was performed with 573 participants from the PREDIMED (Prevención con Dieta Mediterránea) trial (ISRCTN35739639). Total polyphenol levels were measured by a reliable biomarker, total urinary polyphenol excretion (TPE), determined by the Folin-Ciocalteu method in urine samples. Participants were categorized into five groups according to their TPE at the fifth year. Multiple linear regression models were used to assess the relationships between TPE and obesity parameters; body weight (BW), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). After a five years follow up, significant inverse correlations were observed between TPE at the 5th year and BW (β = -1.004; 95% CI: -1.634 to -0.375, p = 0.002), BMI (β = -0.320; 95% CI: -0.541 to -0.098, p = 0.005), WC (β = -0.742; 95% CI: -1.326 to -0.158, p = 0.013), and WHtR (β = -0.408; 95% CI: -0.788 to -0.028, p = 0.036) after adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute to reducing body weight in elderly people at high cardiovascular risk. We thank all the participants of the PREDIMED study. This work was supported in part by CICYT (AGL2016-79113-R), the Instituto de Salud Carlos III, ISCIII (CIBEROBN) from the Spanish Ministry of Economy and Competivity (MEC), and Generalitat de Catalunya (GC) 2014 SGR 773. X.G. received support from China Scholarship Council (CSC). Alexander Medina-Remón thanks the ‘Juan de la Cierva’ postdoctoral program (JCI-2012-13463) from MEC.