6533b7d2fe1ef96bd125eb79

RESEARCH PRODUCT

Elucidating the catalytic reaction mechanism of orotate phosphoribosyltransferase by means of X-ray crystallography and computational simulations

Iñaki TuñónM. Cristina VegaKirill ZinovjevS. GomezSergio Navas-yusteMaite RocaFrancisco J. FernándezMiguel López-estepa

subject

PyrimidineStereochemistry010402 general chemistry01 natural sciencesCatalysisEnzyme catalysischemistry.chemical_compoundOrotidineNucleotideReaction mechanismchemistry.chemical_classificationMD simulations010405 organic chemistryHydrogen bondEnzyme catalysisGeneral ChemistryTautomer0104 chemical sciencesPyrimidine metabolismOrotate phosphoribosyltransferasechemistryPyrimidine metabolismOrotate phosphoribosyltransferaseQM/MM methodsX-ray structure

description

15 p.-8 fig.-2 tab.1 graph. abst.+ 8 fig. supl.-1 tab. supl.

yearjournalcountryeditionlanguage
2020-01-02
10.1021/acscatal.9b05294http://hdl.handle.net/10261/201252