6533b7d3fe1ef96bd1261461
RESEARCH PRODUCT
Spectrophotometric Determination of Hydralazine with 2-Hydroxy-1-naphthaldehyde in Pharmaceuticals
Ramón García-domenechJ. Mańes-vinuesaG. Pous-mirallesJ. Mari-buiguessubject
ChromatographySpectrophotometry Infraredmedicine.diagnostic_testChemistryCalibration curveTemperaturePharmaceutical SciencePropranololHydrogen-Ion ConcentrationNaphthalenesReserpineHydralazineHydralazineDosage formHydrochlorothiazideSpectrophotometrySolventsmedicineIndicators and ReagentsSpectrophotometry Ultravioletmedicine.drugdescription
Abstract A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 °C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40 900 L · mol − 1 · cm − 1 . The method described was applied to the analysis of hydralazine in pharmaceutical preparations containing reserpine, hydrochlorothiazide, bendrofluorthiazine, propranolol, and other substances. The agreement with the U.S.P. XXI method was satisfactory for tablets and injections, but not for pellets.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-07-01 | Journal of Pharmaceutical Sciences |