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RESEARCH PRODUCT
Blunted cortisol response to stress in patients with eating disorders: Its association to bulimic features
Luis Rojo-morenoLaura Rodríguez-santosNieves Fernández-sánchezMaría Isabel Ramos-fuentesLuis Beato-fernándezFrancisco J. Vaz-lealJuan A Guisado-macíasCarlos Alexis Chimpén-lópezFrancisco J Zamora-rodríguezsubject
AdultSalivaAnorexia NervosaHydrocortisoneTrier Social Stress TestPhysiologyeating disorderscortisol03 medical and health sciencesstress0302 clinical medicinemental disordersmedicineTrier social stress testHumansBulimiaBulimia NervosaSalivaAssociation (psychology)business.industryBulimia nervosahypothalamus-pituitary-adrenal axismedicine.disease030227 psychiatryPsychiatry and Mental healthClinical PsychologyEating disordersClinical researchAnorexia nervosa (differential diagnoses)Dexamethasone suppression testbusinessStress Psychological030217 neurology & neurosurgeryhormones hormone substitutes and hormone antagonistsdescription
ObjectiveClinical research on cortisol response to stress in patients with eating disorders has provided controversial and even contradictory results. As this might be the consequence of the inclusion in the studies of heterogeneous clinical populations, 3 highly selected samples were studied. MethodsDexamethasone suppression test was performed on 15 restricting anorexia nervosa patients without history of bulimia nervosa (BN), 17 BN patients with normal weight and no history of anorexia nervosa, and 22 healthy controls. Three days later, the Trier Social Stress Test was applied, and 8 saliva samples were collected along the trial for cortisol assessment. ResultsWhen the patients were considered as a single group, a slightly blunted cortisol response to stress was observed, but when the 3 groups were considered separately, the blunted response was observed only in the BN patients. DiscussionThe results support the association between blunted cortisol response and bulimic features.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-05-30 |