6533b7d6fe1ef96bd1266fe6

RESEARCH PRODUCT

Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment

Janis SpigulisAlexander BykovAlexey LihachevAnton SdobnovAlexey PopovIgor MeglinskiIlze Lihacova

subject

Materials scienceskin cancerspeckle imagingmedicine.diagnostic_testhyperspectral imagingMultispectral imageHyperspectral imagingskin perfusionMicrocirculationSpeckle patternSDG 3 - Good Health and Well-beingSpeckleOptical coherence tomographymedicine/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingSpeckle imagingDiffuse reflectionspeckle contrastPerfusionBiomedical engineering

description

Abstract Laser Speckle Contrast Imaging (LSCI) is a powerful low-cost method for visualization of flow, microcirculation and blood perfusion. Due to the fact that diseased and healthy tissues has different blood perfusion, LSCI can be a perspective tool for cancer diagnostics and discrimination between different types of tissues. Previously, multispectral diffuse reflectance imaging method for melanoma diagnostics has been introduced. In this work, multi-wavelength (532-, 655- and 850- nm) LSCI technique combined with hyperspectral camera and diffuse reflectance imaging method will be used for assessment of tissues with different skin perfusion properties. An in vivo experiment with occlusion in human finger was performed serving as a model of tissues with different perfusion properties. The proposed method still requires further development and improvements to become a real clinical laboratory tool for non-invasive skin cancer diagnostics

yearjournalcountryeditionlanguage
2019-07-22Novel Biophotonics Techniques and Applications V
https://doi.org/10.1117/12.2526921