6533b7d6fe1ef96bd1266fe9
RESEARCH PRODUCT
Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism.
Erkki KolehmainenPavel DrašarManu LahtinenOndřej JurčekOndřej JurčekZdeněk Wimmersubject
Models MolecularMagnetic Resonance SpectroscopyCalorimetry Differential ScanningSpectrophotometry InfraredChemistryPharmaceutical ScienceNuclear magnetic resonance spectroscopyCrystallography X-Raylaw.inventionThermogravimetryCrystallographyDifferential scanning calorimetryProbucolPolymorphism (materials science)Solid-state nuclear magnetic resonancelawThermogravimetryCrystallizationCrystallizationta116Single crystalPowder diffractionPowder Diffractiondescription
Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry, and attenuated total reflection–infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures. Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1794–1802, 2012
year | journal | country | edition | language |
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2011-08-30 | Journal of pharmaceutical sciences |