6533b7d7fe1ef96bd126842b

RESEARCH PRODUCT

Abdominal Wall Endometriosis: Myofibroblasts as a Possible Evidence of Metaplasia: A Case Report

Sylvia MechsnerMohamed IbrahimEleonore DelarueMatthias HaasJalid SehouliVito ChianteraElene Abesadze

subject

AdultPathologymedicine.medical_specialtyStromal cellRectus abdominimedicine.medical_treatmentEndometriosisRectus AbdominisEndometriosisCollagen Type IAbdominal wall03 medical and health sciences0302 clinical medicineMetaplasiaLaparotomymedicineHumansEndometriosiMyofibroblastsActinMetaplasiaMyofibroblast030219 obstetrics & reproductive medicinemedicine.diagnostic_testbusiness.industryAbdominal WallObstetrics and GynecologyMagnetic resonance imagingAnatomymedicine.diseaseMagnetic Resonance ImagingActinsmedicine.anatomical_structureReproductive Medicine030220 oncology & carcinogenesisImmunohistochemistryFemalemedicine.symptombusinessMyofibroblastHuman

description

In this study, we report about a patient with extra-uterine endometriosis (EM) in the abdominal wall muscle with evident metaplasia based on the abundant alpha smooth muscle actin (ASMA)-expressing myofibroblasts. Laparotomy excision of the abdominal wall EM was done following ultrasonographic evidence of a hypodense swelling in the right rectus abdominis, which was confirmed by MRI. Immunohistochemistry staining for ASMA and collagen I was done, with the results confirming that endometriotic stromal cells expressed both. Anterior abdominal wall endometriosis was suspected because of the patient's history of recurrent EM combined with the cyclic nature of symptoms. MRI is useful in determining the extent of the disease. In case of persisting symptoms even under hormonal treatment, surgical excision is mandatory. The expression of both ASMA and collagen I in and around EM lesions supports the notion of the metaplastic process in the course of disease development.

yearjournalcountryeditionlanguage
2016-03-15Gynecologic and Obstetric Investigation
https://doi.org/10.1159/000452101