6533b7d7fe1ef96bd1268d22
RESEARCH PRODUCT
Die Reversibilität der Wirkung von Digitoxin, Strophanthidin und Strophanthidin-3-bromazetat am Papillarmuskel und einer mikrosomalen Na+-K+-aktivierbaren ATPase des Meerschweinchens
W. KlausU. Frickesubject
PharmacologyInotropemedicine.medical_specialtybiologyDigitoxinChemistryATPaseCell BiologyInhibitory postsynaptic potentialCellular and Molecular NeuroscienceEndocrinologymedicine.anatomical_structureInternal medicinebiology.proteinmedicineMicrosomeMolecular MedicineStrophanthidinMolecular BiologyPapillary musclemedicine.drugdescription
The reversibility of the inhibitory action of strophanthidin, strophanthidin-3-bromoacetate, and digitoxin on the Na+-K+-ATPase activity (microsomal fraction, guinea-pig brain) was compared with the rate of decline of their positive inotropic effects (papillary muscle, guinea-pig heart) after exposure to drug-free solution. The actions of strophanthidin and digitoxin were easily reduced on both systems. Strophanthidin-3-bromoacetate, however, was found to have an irreversible blocking effect on the transport ATPase, whereas its inotropic action could be rapidly abolished.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1969-07-01 | Experientia |