Chlamyphilone, a Novel Pochonia chlamydosporia Metabolite with Insecticidal Activity

6533b7d7fe1ef96bd1268f2a

RESEARCH PRODUCT

Chlamyphilone, a Novel Pochonia chlamydosporia Metabolite with Insecticidal Activity

Sheridan L. Woo Francesco Vinale Maria Cristina Digilio Federica Lacatena Matteo Lorito Alessandro Piccolo Pierluigi Mazzei Pierpaolo Cavallo Roberta Marra Massimo Giorgini

subject

0106 biological sciences Penicillium griseofulvum Insecticides Magnetic Resonance Spectroscopy Metabolite Pharmaceutical Science Metarhizium anisopliae Beauveria bassiana beneﬁcial microbes Bassiana 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Ascomycota lcsh:Organic chemistry Drug Discovery Food science Physical and Theoretical Chemistry Biological Products biology Molecular Structure 010405 organic chemistry Chemistry secondary metabolites Organic Chemistry fungi food and beverages pea aphid biology.organism_classification Griseofulvin azaphilones Beauvericin 0104 chemical sciences Acyrthosiphon pisum 010602 entomology beneficial microbes Chemistry (miscellaneous)Molecular Medicine secondary metabolites; beneﬁcial microbes; pea aphid; azaphilones

description

Metabolites from a collection of selected fungal isolates have been screened for insecticidal activity against the aphid Acyrthosiphon pisum. Crude organic extracts of culture filtrates from six fungal isolates (Paecilomyces lilacinus, Pochonia chlamydosporia, Penicillium griseofulvum, Beauveria bassiana, Metarhizium anisopliae and Talaromyces pinophilus) caused mortality of aphids within 72 h after treatment. In this work, bioassay-guided fractionation has been used to characterize the main bioactive metabolites accumulated in fungal extracts. Leucinostatins A, B and D represent the bioactive compounds produced by P. lilacinus. From P. griseofulvum and B. bassiana extracts, griseofulvin and beauvericin have been isolated, respectively

year	journal	country	edition	language
2019-02-01	Molecules

10.3390/molecules24040750 https://www.mdpi.com/1420-3049/24/4/750

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