Pembrolizumab as Consolidation Strategy in Patients with Multiple Myeloma: Results of the GEM-Pembresid Clinical Trial

6533b7d8fe1ef96bd1269ae8

RESEARCH PRODUCT

Pembrolizumab as Consolidation Strategy in Patients with Multiple Myeloma: Results of the GEM-Pembresid Clinical Trial

N. Puig Luis Antonio Corchete Sánchez J. J. Pérez-morán J. Dávila T. Paíno J. De La Rubia Albert Oriol J. Martín-sánchez F. De Arriba J. Bladé M. J. Blanchard V. González-calle R. Garcia-sanz Bruno Paiva J. J. Lahuerta J. F. San-miguel M. V. Mateos E. M. Ocio Universitat Autònoma De Barcelona

subject

0301 basic medicine Oncology Melphalan Cancer Research medicine.medical_specialty medicine.medical_treatment Pembrolizumab lcsh:RC254-282 Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adverse effect Multiple myeloma Pneumonitis business.industry Late effect Immunotherapy medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Discontinuation 030104 developmental biology myeloma Oncology 030220 oncology & carcinogenesis pembrolizumab immunotherapy medicine.symptom business consolidation medicine.drug

description

PD1 expression in CD4+ and CD8+ T cells is increased after treatment in multiple myeloma patients with persistent disease. The GEM-Pembresid trial analyzed the efficacy and safety of pembrolizumab as consolidation in patients achieving at least very good partial response but with persistent measurable disease after first- or second-line treatment. Moreover, the characteristics of the immune system were investigated to identify potential biomarkers of response to pembrolizumab. One out of the 17 evaluable patients showed a decrease in the amount of M-protein, although a potential late effect of high-dose melphalan could not be ruled out. Fourteen adverse events were considered related to pembrolizumab, two of which (G3 diarrhea and G2 pneumonitis) prompted treatment discontinuation and all resolving without sequelae. Interestingly, pembrolizumab induced a decrease in the percentage of NK cells at cycle 3, due to the reduction of the circulating and adaptive subsets (0.615 vs. 0.43, p = 0.007

year	journal	country	edition	language
2020-12-03

https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4659

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