6533b7d9fe1ef96bd126d571
RESEARCH PRODUCT
A new and expeditious strategy for the synthesis of β-amino acids from Δ2-oxazolines
Enrique AguilarSantos FusteroMa Dolores DíazEsther SalavertAntonio Hidalgo Navarrosubject
chemistry.chemical_classificationChemistryOrganic ChemistryDrug DiscoveryMoietyOrganic chemistryChemoselectivityBiochemistryAmino aciddescription
Abstract A new, mild two-step synthesis of racemic β-amino acids starting from 2-alkyl-Δ2-oxazolines is described. The process implies the initial formation of masked N-substituted or N-unsubstituted β-enamino acid derivatives followed by chemoselective reduction of the enamino moiety. The process takes place with high yields, total chemoselectivity and moderate diastereoselectivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-01-01 | Tetrahedron |