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RESEARCH PRODUCT
Neuroprotective and Mitoprotective Effects of Lemon IntegroPectin on SH-SY5Y Cells
Laura M. IlharcoAlessandro PresentatoMario PagliaroAlexandra FidalgoFrancesco MeneguzzoRosa AlduinaDomenico NuzzoMiriana ScordinoCostanza GiardinaDi LibertoAntonino ScurriaGiuseppa MudòPasquale Massimo PiconeRosaria Ciriminnasubject
chemistry.chemical_classificationReactive oxygen speciesCell signalingSH-SY5YchemistrymedicineViability assayMitochondrionmedicine.disease_causeCell morphologyNeuroprotectionOxidative stressCell biologydescription
AbstractLemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro, as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with H2O2. Mediated by ROS including H2O2 and its derivatives, oxidative stress alters numerous cellular processes, including mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, support further investigations to verify its activity in preventing, retarding, or even curing neurological diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-10 |