6533b7dafe1ef96bd126e139
RESEARCH PRODUCT
Affinity Sensors for the Diagnosis of COVID-19
Maryia DrobyshRoman ViterArunas RamanaviciusAlmira Ramanavicienesubject
AnalyteCoronavirus disease 2019 (COVID-19)Computer scienceimmune complexSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)lcsh:Mechanical engineering and machinerySARS-CoV-2 virus02 engineering and technologyReviewelectrochemical immunosensors03 medical and health sciencesCOVID-19 ; SARS-CoV-2 virus ; RNA analysis ; bioelectrochemistry ; biosensors ; electro- chemical immunosensors ; antigen-antibody interaction ; immune complex ; molecularly imprinted polymers (MIPs) ; surface modification by immobilization of biomoleculesElectrochemical biosensorDetection theorylcsh:TJ1-1570Electrical and Electronic EngineeringSurface plasmon resonance030304 developmental biologysurface modification by immobilization of biomolecule0303 health sciencesMechanical EngineeringbioelectrochemistryCOVID-19surface modification by immobilization of biomoleculesRNA analysis021001 nanoscience & nanotechnologybiosensorsAntigen-antibody interactionControl and Systems Engineeringmolecularly imprinted polymers (MIPs)antigen-antibody interaction0210 nano-technologyBiological systemBiosensordescription
The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020. Reducing the dissemination rate, in particular by tracking the infected people and their contacts, is the main instrument against infection spreading. Therefore, the creation and implementation of fast, reliable and responsive methods suitable for the diagnosis of COVID-19 are required. These needs can be fulfilled using affinity sensors, which differ in applied detection methods and markers that are generating analytical signals. Recently, nucleic acid hybridization, antigen-antibody interaction, and change of reactive oxygen species (ROS) level are mostly used for the generation of analytical signals, which can be accurately measured by electrochemical, optical, surface plasmon resonance, field-effect transistors, and some other methods and transducers. Electrochemical biosensors are the most consistent with the general trend towards, acceleration, and simplification of the bioanalytical process. These biosensors mostly are based on the determination of antigen-antibody interaction and are robust, sensitive, accurate, and sometimes enable label-free detection of an analyte. Along with the specification of biosensors, we also provide a brief overview of generally used testing techniques, and the description of the structure, life cycle and immune host response to SARS-CoV-2, and some deeper details of analytical signal detection principles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 | Micromachines |