6533b7dafe1ef96bd126e157

RESEARCH PRODUCT

Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis.

Armin SzegediIon AnghelescuChristoph KlaweHubertus HimmerichMatthias J. Müller

subject

Malemedicine.medical_specialtyPsychosisMultiple Sclerosismedicine.medical_treatmentPyridinium CompoundsSuicide AttemptedBlood–brain barrierPsychoses Substance-InducedCentral nervous system diseasechemistry.chemical_compoundBromidemedicineHumansDistigminePsychiatric Status Rating ScalesChemotherapybusiness.industryMultiple sclerosisUrinary Retentionmedicine.diseasePathophysiologySurgeryPsychiatry and Mental healthmedicine.anatomical_structurechemistryParasympathomimeticsAnesthesiaFemalebusinessmedicine.drug

description

AbstractA female patient with multiple sclerosis (MS) suffered from an acute psychotic disorder after taking distigmine bromide for detrusor dysfunction. She showed a dramatic relief of her symptoms after the medication, distigmine bromide, was stopped. Distigmine is not supposed to penetrate the blood-brain barrier (BBB). However, in MS patients a leakage of the BBB could be hypothesized.

yearjournalcountryeditionlanguage
2003-10-01European psychiatry : the journal of the Association of European Psychiatrists
10.1016/j.eurpsy.2002.11.001https://pubmed.ncbi.nlm.nih.gov/14611928