Effects of Plant Sterols or β-Cryptoxanthin at Physiological Serum Concentrations on Suicidal Erythrocyte Death.

6533b7dafe1ef96bd126e274

RESEARCH PRODUCT

Effects of Plant Sterols or β-Cryptoxanthin at Physiological Serum Concentrations on Suicidal Erythrocyte Death.

Amparo Alegría Alessandro Attanzio Luisa Tesoriere Andrea Alvarez-sala Gabriel López-garcía Antonio Cilla Reyes Barberá

subject

0301 basic medicine Hemolysi Erythrocytes Campesterol Beta-Cryptoxanthin Eryptosis Stigmasterol Pharmacology medicine.disease_cause Hemolysis β-cryptoxanthin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine tert-Butylhydroperoxide medicine Humans Cells Cultured phytosterol oxidative stre Stigmasterol Chemistry Cholesterol Phytosterol Chemistry (all)Phytosterols General Chemistry Glutathione medicine.disease Sitosterol Glutathione Sitosterols Hemolysis Erythrocyte Oxidative Stress 030104 developmental biology Cholesterol Agricultural and Biological Sciences (all)030220 oncology & carcinogenesis eryptosi General Agricultural and Biological Sciences Intracellular Oxidative stress Human

description

The eryptotic and hemolytic effects of a phytosterol (PS) mixture (β-sitosterol, campesterol, stigmasterol) or β-cryptoxanthin (β-Cx) at physiological serum concentration and their effect against oxidative stress induced by tert-butylhydroperoxide (tBOOH) (75 and 300 μM) were evaluated. β-Cryptoxanthin produced an increase in eryptotic cells, cell volume, hemolysis, and glutathione depletion (GSH) without ROS overproduction and intracellular Ca2+influx. Co-incubation of both bioactive compounds protected against β-Cx-induced eryptosis. Under tBOOH stress, PS prevented eryptosis, reducing Ca2+influx, ROS overproduction and GSH depletion at 75 μM, and hemolysis at both tBOOH concentrations. β-Cryptoxanthin showed no cytoprotective effect. Co-incubation with both bioactive compounds completely prevented hemolysis and partially prevented eryptosis as well as GSH depletion induced by β-Cx plus tBOOH. Phytosterols at physiological serum concentrations help to prevent pro-eryptotic and hemolytic effects and are promising candidate compounds for ameliorating eryptosis-associated diseases.

year	journal	country	edition	language
2018-01-27	Journal of agricultural and food chemistry

10.1021/acs.jafc.7b05575 https://pubmed.ncbi.nlm.nih.gov/29345907

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