6533b7dafe1ef96bd126e351

RESEARCH PRODUCT

GLP-2: What do we know? What are we going to discover?

Antonella AmatoSara Baldassano

subject

Agonistendocrine systemmedicine.medical_specialtyPhysiologymedicine.drug_classClinical BiochemistryEnteroendocrine cellBiologySettore BIO/09 - FisiologiaBiochemistryEnteric Nervous SystemCellular and Molecular NeuroscienceEndocrinologyInternal medicineGlucagon-Like Peptide 2medicineAnimalsHumansGlucose homeostasisReceptorInflammationdigestive oral and skin physiologyShort bowel syndromemedicine.diseaseIntestinal epitheliumGastrointestinal TractEndocrinologyGLP-2 GLP-2 receptor gastrointestinal tract enteric nervous systemEnteric nervous systemGastrointestinal functionNeurosciencehormones hormone substitutes and hormone antagonistsSignal Transduction

description

Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis. The aim of this review is to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the enteric modulation of the gastrointestinal function and to focus on new works in order to present an innovative picture of GLP-2.

yearjournalcountryeditionlanguage
2014-11-01Regulatory Peptides
https://doi.org/10.1016/j.regpep.2014.09.002