6533b7dafe1ef96bd126e397
RESEARCH PRODUCT
Clinical patterns and electrophysiological findings in retinal pigment epithelium diseases. Does a correlation exist?
M. AnastasiFrancesco PonteSalvatore Cillinosubject
AdultMalePathologymedicine.medical_specialtyAdolescentBasic scienceEye diseasemacromolecular substancesBiologyCorrelationRetinal DiseasesPhysiology (medical)medicineElectroretinographyHumansChildPigment Epithelium of EyeAgedRetinaRetinal pigment epitheliummedicine.diagnostic_testMiddle Agedmedicine.diseaseSensory SystemsOphthalmologyElectrophysiologyElectrooculographymedicine.anatomical_structureFemalesense organsElectroretinographyRetinopathydescription
At present it is difficult to distinguish those human chorioretinal diseases in which the retinal pigment epithelium (RPE) is the primary site of dysfunction. This difficulty is caused by several factors such as scarcity of biochemical and histological information and a lack of correlation of basic science information available with the clinical body of knowledge. In the present study we examined 134 eyes at early or late stages of hereditary diseases involving the RPE. We tried to distinguish primary RPE involvement by using standard ERG (a- and b-wave) and EOG testing. We conclude that in general primary RPE damage can be better assessed by current electrophysiology in those diseases which seem to remain localized at the RPE level for a long time.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-01-31 | Documenta ophthalmologica. Advances in ophthalmology |