Disease expression in women with hereditary angioedema

6533b7dafe1ef96bd126f5db

RESEARCH PRODUCT

Disease expression in women with hereditary angioedema

Denise Ponard Teresa Caballero C. Massot Isabelle Boccon-gibod Christophe Bucher Marco Cicardi Anette Bygum Henriette Farkas Konrad Bork Erik Waage Nielsen Hilary Longhurst Laurence Bouillet Christian Drouet

subject

Pediatrics Disease MESH: Hormones MESH: Pregnancy 0302 clinical medicine Pregnancy MESH: Progesterone MESH: Child Immunopathology MESH: Contraceptives Oral Combined MESH: Puberty 030212 general & internal medicine skin and connective tissue diseases Progesterone media_common MESH: Middle Aged MESH: Complement Hemolytic Activity Assay MESH: Angioedema Hereditary Vaginal delivery food and beverages Obstetrics and Gynecology MESH: Complement C4 [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged Menstruation 3. Good health Contraceptives Oral Combined MESH: Pregnancy Complications Pill Hereditary angioedema Female medicine.symptom Adult medicine.medical_specialty MESH: Pedigree MESH: Complement C1 Inactivator Proteins MESH: Menstruation [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics 03 medical and health sciences medicine MESH: Angioedema Humans media_common.cataloged_instance European union Pregnancy MESH: Humans Angioedema business.industry Puberty Angioedemas Hereditary MESH: Adult Delivery Obstetric medicine.disease Hormones MESH: Recurrence Surgery MESH: Abdominal Pain Pregnancy Complications 030228 respiratory system MESH: Delivery Obstetric business MESH: Female

description

Udgivelsesdato: 2008-Jun-11 OBJECTIVE: Fluctuations in sex hormones can trigger angioedema attacks in women with hereditary angioedema. Combined oral contraceptive therapies, as well as pregnancy, can induce severe attacks. The course of angioedema may be very variable in different women. STUDY DESIGN: Within the PREHAEAT project launched by the European Union, data on 150 postpubertal women with hereditary angioedema were collected in 8 countries, using a patient-based questionnaire. RESULTS: Puberty worsened the disease for 62%. Combined oral contraceptives worsened the disease for 79%, whereas progestogen-only pills improved it for 64%. During pregnancies, 38% of women had more attacks, but 30% had fewer attacks. Vaginal delivery was usually uncomplicated. Attacks occurred within 48 hours in only 6% of cases. Those more severely affected during menses had more symptoms during pregnancies, suggesting a hormone-sensitive phenotype for some patients. CONCLUSION: The course of angioedema in women with C1 inhibitor deficiency is affected by physiologic hormonal changes; consequently, physicians should take these into account when advising on management.

year	journal	country	edition	language
2008-11-01	American Journal of Obstetrics and Gynecology

https://doi.org/10.1016/j.ajog.2008.04.034