6533b7dbfe1ef96bd126f7a4

RESEARCH PRODUCT

Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants

Pablo DualdeJulia KuligowskiMáximo VentoFrancisca Corpas-burgosAgustín PastorOlga PardoMaría GormazVicent Yusà

subject

AdultTolerable daily intakeendocrine systemPercentileEnvironmental Engineering010504 meteorology & atmospheric sciencesBisphenol FBisphenolMothers010501 environmental sciences01 natural sciencesPhenolsEnvironmental healthBiomonitoringHumansEnvironmental ChemistryMedicineSulfonesBenzhydryl CompoundsWaste Management and DisposalRisk assessment0105 earth and related environmental sciencesMilk HumanProbabilistic risk assessmenturogenital systembusiness.industryHuman milkInfantBisphenolPollutionHuman biomonitoringBreast FeedingMaternal ExposureSpainEnvironmental PollutantsFemaleGeometric meanbusinessRisk assessmentInfantshormones hormone substitutes and hormone antagonistsEnvironmental Monitoring

description

The present study addresses the presence of bisphenols A (BPA) and its analogs bisphenol F (BPF) and S (BPS) in milk of 120 mothers living in Valencia (Spain) and participating in the BETTERMILK project (year 2015). We also studied the factors that could influence the BPA levels and estimated the exposure and the risk for breast fed infants. The frequency of detection of total (conjugated + unconjugated) and unconjugated-BPA were 83% and 77%. with a geometric mean of 0.29 ng/mL and 0.15 ng/mL, respectively. The frequency of detection was much lower for total-BPF (22%) and total-BPS (1.1%). The place of residence of the mother and the use of personal care products showed significant association with BPA concentrations. The estimated daily intake of total-BPA for breastfed infants amounted to a geometric mean of 0.04 mu g/kg bw and a 95th percentile of 1.0 mu g,/kg bw, below the tolerable daily intake of 4 mu g/kg bw-day established by EFSA. To our knowledge, this is the largest biomonitoring study of bisphenols in human milk in Europe. (C) 2019 Elsevier B.V. All rights reserved.

yearjournalcountryeditionlanguage
2019-01-01Science of The Total Environment
https://doi.org/10.1016/j.scitotenv.2019.03.024