Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry

6533b7dcfe1ef96bd1272124

RESEARCH PRODUCT

Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry

Gw Canonica F. Blasi Pl. Senna G. E. Paggiaro G. Passalacqua A. Spanevello S. Aliberti D. Bagnasco M. Bonini M. Bonavia C. Bucca L. Brussino M. F. Caiaffa C. Calabrese G. Camiciottoli M. Caminati G. E. Carpagnano C. Caruso S. Centanni M. E. Conte A. G. Corsico L. Cosmi M. T. Costantino N. Crimi S. D’alo M. D’amato S. Del Giacco A. Farsi E. Favero M. P. Foschino Barbaro G. Guarnieri G. Guida M. Latorre S. Lo Cicero C. Lombardi L. Macchia F. Mazza F. Menzella M. Milanese I. M. Montagn P. Montuschi E. Nucera R. Parente V. Patella G. Pelaia L. Pini F. Puggioni L. Ricciardi F. L. M. Ricciardolo L. Richeldi E. Ridolo G. Rolla P. Santus N. Scichilone G. Spadaro Mr. Yacoub A. Vianello V. Viviano M. C. Zappa &Amp;E. Heffler

subject

Pulmonary and Respiratory Medicine Adult Male medicine.medical_specialty Severe asthma Databases Factual Administration Oral Comorbidity Settore MED/10 - Malattie Dell'Apparato Respiratorio Nitric Oxide Severity of Illness Index Comorbidities Oral corticosteroid Adrenal Cortex Hormones Internal medicine Severity of illness Oral corticosteroids medicine Prevalence Nasal polyps Humans Nasal polyps Registries Sinusitis Sinusitis Asthma Aged Rhinitis Internet Bronchiectasis business.industry Nasal polyp Settore MED/09 - MEDICINA INTERNA Atopic dermatitis Comorbidities; Nasal polyps; Oral corticosteroids; Severe asthma Middle Aged medicine.disease Comorbidity Asthma Comorbidities Nasal polyps Oral corticosteroids Severe asthma Italy Concomitant Chronic Disease Disease Progression Female Comorbiditie business

description

Abstract Background The clinical and laboratory features of patients enrolled in the Severe Asthma Network in Italy (SANI) registry, a web-based observatory collecting demographic, clinical, functional and inflammatory data of patients with severe asthma were evaluated, with a special emphasis to chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods For each eligible patients the following information has been collected: demographic data, clinical features, asthma control in the previous month according to the GINA (Global INitiative for Asthma) Guidelines and standardized questionnaires, concomitant regular and on demand treatments and inflammatory markers. Results 695 patients with severe asthma enrolled in 66 SANI centers were analyzed. The prevalence of chronic rhinosinusitis with nasal polyposis was 40.6%. Atopic dermatitis and bronchiectasis was significantly more frequent in patients with CRSwNP than in subjects without nasal polyposis; similarly, FeNO values are significantly higher in subject with CRSwNP than in patients without nasal polyposis. Finally, patients with CRSwNP had a significantly higher number of asthma exacerbations per year, more days on oral corticosteroids and were more likely to be OCS long term users. Conclusion OCS sparing is needed in patients with severe asthma, mainly in subjects with CRSwNP, adopting adequate strategies such as a better adherence to the treatment with inhaled therapy according to the GINA recommendations, the use of biologic agents and a multidisciplinary approach of the patient.

year	journal	country	edition	language
2020-01-01

10.1016/j.rmed.2020.105947 http://hdl.handle.net/2318/1737494